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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 16 of 16 1 Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages. Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020 BASE Show details 2 Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages. Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020 BASE Show details 3 Taking the sublexical route: brain dynamics of reading in the semantic variant of primary progressive aphasia Borghesani, Valentina; Hinkley, Leighton B N; Ranasinghe, Kamalini G... In: Brain (2020) BASE Show details 4 Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages Shdo, Suzanne M.; Ranasinghe, Kamalini G.; Sturm, Virginia E.... In: Front Neurol (2020) BASE Show details 5 Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. Toller, Gianina; Yang, Winson FZ; Brown, Jesse A... In: Toller, Gianina; Yang, Winson FZ; Brown, Jesse A; Ranasinghe, Kamalini G; Shdo, Suzanne M; Kramer, Joel H; et al.(2019). Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. NeuroImage. Clinical, 22, 101729. doi:10.1016/j.nicl.2019.101729. UCSF: Retrieved from: http://www.escholarship.org/uc/item/9qm527cr (2019) BASE Show details 6 Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019 BASE Show details 7 Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. Toller, Gianina; Yang, Winson FZ; Brown, Jesse A. - : eScholarship, University of California, 2019 BASE Show details 8 Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease. Ranasinghe, Kamalini G; Kothare, Hardik; Kort, Naomi... In: Ranasinghe, Kamalini G; Kothare, Hardik; Kort, Naomi; Hinkley, Leighton B; Beagle, Alexander J; Mizuiri, Danielle; et al.(2019). Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease. Scientific reports, 9(1), 5686. doi:10.1038/s41598-019-41794-x. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3170w5cs (2019) BASE Show details 9 Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease. Ranasinghe, Kamalini G; Kothare, Hardik; Kort, Naomi... In: Scientific reports, vol 9, iss 1 (2019) BASE Show details 10 Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease. Ranasinghe, Kamalini G; Kothare, Hardik; Kort, Naomi; Hinkley, Leighton B; Beagle, Alexander J; Mizuiri, Danielle; Honma, Susanne M; Lee, Richard; Miller, Bruce L; Gorno-Tempini, Maria Luisa; Vossel, Keith A; Houde, John F; Nagarajan, Srikantan S In: Scientific reports, vol 9, iss 1 (2019) Abstract: Accurate integration of sensory inputs and motor commands is essential to achieve successful behavioral goals. A robust model of sensorimotor integration is the pitch perturbation response, in which speakers respond rapidly to shifts of the pitch in their auditory feedback. In a previous study, we demonstrated abnormal sensorimotor integration in patients with Alzheimer's disease (AD) with an abnormally enhanced behavioral response topitch perturbation. Here we examine the neural correlates of the abnormal pitch perturbation response in AD patients, using magnetoencephalographic imaging. The participants phonated the vowel /α/ while a real-time signal processor briefly perturbed the pitch(100 cents, 400 ms) of their auditory feedback. We examined the high-gamma band (65-150 Hz) responses during this task. AD patients showed significantly reduced left prefrontal activity during the early phase of perturbation and increased right middle temporal activity during the later phase of perturbation, compared to controls. Activity in these brain regions significantly correlated with the behavioral response. These results demonstrate that impaired prefrontal modulation of speech-motor-control network and additional recruitment of right temporal regions are significant mediators of aberrant sensorimotor integration in patients with AD. The abnormal neural integration mechanisms signify the contribution of cortical network dysfunction to cognitive and behavioral deficits in AD. Keyword: 2.1 Biological and endogenous factors; Acoustic Stimulation; Acquired Cognitive Impairment; Aging; Alzheimer Disease; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Basic Behavioral and Social Science; Behavioral and Social Science; Brain; Brain Disorders; Clinical Research; Dementia; Feedback; Female; Humans; Male; Middle Aged; Neurodegenerative; Neurological; Neurosciences; Phonation; Pitch Perception; Rehabilitation; Sensory; Speech URL: https://escholarship.org/uc/item/3170w5cs BASE Hide details 11 Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity Toller, Gianina; Yang, Winson F.Z.; Brown, Jesse A.. - : Elsevier, 2019 BASE Show details 12 Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer’s disease Ranasinghe, Kamalini G.; Kothare, Hardik; Kort, Naomi. - : Nature Publishing Group UK, 2019 BASE Show details 13 Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants Ranasinghe, Kamalini G; Hinkley, Leighton B; Beagle, Alexander J. - : Oxford University Press, 2017 BASE Show details 14 Deconstructing empathy: Neuroanatomical dissociations between affect sharing and prosocial motivation using a patient lesion model Shdo, Suzanne M.; Ranasinghe, Kamalini G.; Gola, Kelly A.. - 2017 BASE Show details 15 Regional functional connectivity predicts distinct cognitive impairments in Alzheimer’s disease spectrum Ranasinghe, Kamalini G.; Hinkley, Leighton B.; Beagle, Alexander J.. - : Elsevier, 2014 BASE Show details 16 Discrimination of brief speech sounds is impaired in rats with auditory cortex lesions Porter, Benjamin A.; Rosenthal, Tara R.; Ranasinghe, Kamalini G.. - 2010 BASE Show details

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