| 21 |
Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms
|
|
|
|
Abstract:
In this study, we investigated the relaxation effect and mechanisms of patchouli alcohol (PA) on rat corpus cavernosum. Corpus cavernosum strips were used in organ baths for isometric tension studies. The results showed that PA demonstrated concentration-dependent relaxation effect on rat corpus cavernosum. The relaxant response to PA was not influenced by tetrodotoxin and atropine while it was significantly inhibited by removal of endothelium. L-N(G)-nitroarginine methyl ester (L-NAME, a nitric oxide synthase inhibitor) or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, a soluble guanylate cyclase inhibitor) significantly inhibited relaxation response to PA, whereas indomethacin (COX inhibitor) had no effect on PA-induced relaxation. The treatment of endothelium-deprived corpus cavernosum with several potassium channel blockers including tetraethylammonium (TEA), 4-aminopyridine (4-AP), and glibenclamide had no effect on PA-induced relaxation. Endothelium-deprived corpus cavernosal contractions induced by cumulative addition of Ca(2+) to high KCl solution without CaCl(2) were significantly inhibited by PA. Also, PA improved relaxant capacity of sildenafil in rat corpus cavernosum. In addition, the perfusion with PA significantly increased the levels of cGMP and expression of mRNA and protein of neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS). Furthermore, intracavernous injection of PA enhanced the rise in intracavernous pressure in rats during cavernosal nerve electric stimulation. In conclusion, PA relaxed the rat corpus cavernosum attributed to both endothelium-dependent and -independent properties. While the former component was mostly involved in nitric oxide signaling pathway, the endothelium-independent mechanism involved in PA-induced relaxation was probably linked to calcium antagonism.
|
|
Keyword:
Research Article
|
|
URL: https://doi.org/10.1155/2020/3109069
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066398/
|
|
BASE
|
|
Hide details
|
|
|
| 22 |
Inheritance Study on the Culture of Traditional Music in Middle and Primary Education: Taking South Korean Music Curriculum as an Example
|
|
|
|
In: Cross-Cultural Communication; Vol 16, No 3 (2020): Cross-Cultural Communication; 22-24 ; 1923-6700 ; 1712-8358 (2020)
|
|
BASE
|
|
Show details
|
|
|
| 25 |
Simplified Neutrosophic Linguistic NormalizedWeighted Bonferroni Mean Operator and Its Application to Multi-Criteria Decision-Making Problems ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 26 |
Simplified Neutrosophic Linguistic NormalizedWeighted Bonferroni Mean Operator and Its Application to Multi-Criteria Decision-Making Problems ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 27 |
Wearable Ankle Robots in Post-stroke Rehabilitation of Gait: A Systematic Review
|
|
|
|
BASE
|
|
Show details
|
|
|
| 28 |
Hearing, speech reception, vocabulary and language: population epidemiology and concordance in Australian children aged 11 to 12 years and their parents
|
|
|
|
BASE
|
|
Show details
|
|
|
| 29 |
Cerebral functional abnormalities in patients with nasopharyngeal carcinoma after radiotherapy: an observational magnetic resonance resting-state study
|
|
|
|
BASE
|
|
Show details
|
|
|
| 30 |
Person-Centered Dementia Care in China: A Bilingual Literature Review
|
|
|
|
BASE
|
|
Show details
|
|
|
| 31 |
Information seeking behaviour of early-career translators in Chinese to English and English to Chinese two-way translation.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 32 |
Measurement of prompt and nonprompt charmonium suppression in $\text {PbPb}$ collisions at 5.02 $\,\text {Te}\text {V}$
|
|
|
|
In: Eur.Phys.J.C ; https://hal.archives-ouvertes.fr/hal-01833739 ; Eur.Phys.J.C, 2018, 78 (6), pp.509. ⟨10.1140/epjc/s10052-018-5950-6⟩ (2018)
|
|
BASE
|
|
Show details
|
|
|
| 34 |
Cross-sectional epidemiology of hearing loss in Australian children aged 11-12 years old and 25-year secular trends
|
|
|
|
BASE
|
|
Show details
|
|
|
| 35 |
Robot Evaluation and Selection with Entropy-Based Combination Weighting and Cloud TODIM Approach
|
|
|
|
In: Entropy (Basel) (2018)
|
|
BASE
|
|
Show details
|
|
|
| 37 |
Measurement of prompt and nonprompt charmonium suppression in $\text {PbPb}$ collisions at 5.02 $\,\text {Te}\text {V}$
|
|
|
|
BASE
|
|
Show details
|
|
|
| 38 |
Multi-Criteria Decision-Making Based On Generalized Prioritized Aggregation Operators Under Simplified Neutrosophic Uncertain Linguistic Environment ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 39 |
Multi-Criteria Decision-Making Based On Generalized Prioritized Aggregation Operators Under Simplified Neutrosophic Uncertain Linguistic Environment ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 40 |
Textbook Writers’ Perspectives on Theoretical Frameworks in Beginning and Intermediate Chinese Textbooks
|
|
|
|
In: Author (2017)
|
|
BASE
|
|
Show details
|
|
|
|
|
