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Intelligent Assistant Systems: An Artificial Intelligence Approach to Detecting Performance Degradation and Pilot Incapacitation
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In: DTIC AND NTIS (1990)
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82 |
Removal of Noise from Noise-Degraded Speech Signals. Panel on Removal of Noise from a Speech/Noise Signal
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In: DTIC AND NTIS (1989)
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83 |
Performance Analysis of Large Adaptive Sidelobe Canceller Arrays with Reused Elements
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In: DTIC AND NTIS (1989)
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84 |
The Effects of Hearing Protectors on Speech Communication and the Perception of Warning Signals
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In: DTIC AND NTIS (1989)
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85 |
Intelligibility of ICAO (International Civil Aviation Organization) Spelling Alphabet Words and Digits Using Severely Degraded Speech Communication Systems. Part 1. Narrowband Digital Speech.
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In: DTIC AND NTIS (1987)
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86 |
Voice Degradation in Using Speech Recognisers for Transcribing Inventory Data.
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In: DTIC AND NTIS (1987)
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87 |
Two Approaches to Predictive Indeterminacy
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In: Linguistics Faculty Publications (1984)
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88 |
Evidence for defective transfer ribonucleic acid in polymyopathic hamsters and its inhibitory effect on protein synthesis
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89 |
Multiplexing of Delta Modulated Signals. Volume 1.
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In: DTIC AND NTIS (1968)
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90 |
ADVANCED ECM SUSCEPTIBILITY MEASUREMENT OF VOICE COMMUNICATIONS EQUIPMENTS.
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In: DTIC AND NTIS (1967)
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92 |
LETTER TO THE EDITOR Conventional 39 end formation is not required for NMD substrate recognition in Saccharomyces cerevisiae
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In: http://www.case.edu/med/coller/Baker and Parker 2006.pdf
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Abstract:
The recognition and rapid degradation of mRNAs with premature translation termination codons by the nonsense-mediated pathway of mRNA decay is an important RNA quality control system in eukaryotes. In mammals, the efficient recognition of these mRNAs is dependent upon exon junction complex proteins deposited on the RNA during pre-mRNA splicing. In yeast, splicing does not play a role in recognition of mRNAs that terminate translation prematurely, raising the possibility that proteins deposited during alternative pre-mRNA processing events such as 39 end formation might contribute to the distinction between normal and premature translation termination. We have utilized mRNAs with a 39 poly(A) tail generated by ribozyme cleavage to demonstrate that the normal process of 39 end cleavage and polyadenylation is not required for mRNA stability or the detection of a premature stop codon. Thus, in yeast, the distinction between normal and premature translation termination events is independent of both splicing and conventional 39 end formation.
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Keyword:
39 end formation; mRNA degradation; nonsense-mediated mRNA decay; poly(A) binding; translation termination
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URL: http://www.case.edu/med/coller/Baker and Parker 2006.pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.532.5216
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