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1
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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2
Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism
In: Journal of Clinical Medicine; Volume 11; Issue 8; Pages: 2260 (2022)
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3
Pilotstudie zur parodontalen Gesundheit bei Patienten mit frontotemporaler Demenz ...
Baumgartner, Monika. - : Universität Ulm, 2022
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4
A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
Patel, Nikil; Peterson, Katie A; Ingram, Ruth U. - : Apollo - University of Cambridge Repository, 2022
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5
A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
Patel, Nikil; Peterson, Katie A; Ingram, Ruth U. - : Apollo - University of Cambridge Repository, 2022
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6
Temporal cognition: subjective time and its connection with memory in frontotemporal dementia
Liu, Lulu. - : The University of Sydney, 2022. : Faculty of Science, School of Psychology, 2022
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7
Improving the diagnostic accuracy of primary progressive aphasia using cognitive tests
Foxe, David Gordon. - : The University of Sydney, 2022. : Faculty of Science, School of Psychology, 2022
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8
Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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9
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021
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10
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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11
Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults.
Rankin, Katherine P; Toller, Gianina; Gavron, Lauren. - : eScholarship, University of California, 2021
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12
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021
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13
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
Magrath Guimet, Nahuel; Miller, Bruce L; Allegri, Ricardo F. - : eScholarship, University of California, 2021
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14
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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15
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
Magrath Guimet, Nahuel; Miller, Bruce L; Allegri, Ricardo F. - : eScholarship, University of California, 2021
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16
Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia. ...
Benussi, Alberto; Alberici, Antonella; Samra, Kiran. - : Apollo - University of Cambridge Repository, 2021
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17
Application of Machine Learning to Electroencephalography for the Diagnosis of Primary Progressive Aphasia: A Pilot Study
In: Brain Sciences ; Volume 11 ; Issue 10 (2021)
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18
Verbal Short-Term Memory Disturbance in the Primary Progressive Aphasias: Challenges and Distinctions in a Clinical Setting
In: Brain Sciences ; Volume 11 ; Issue 8 (2021)
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19
Cognitive and Neural Mechanisms of Social Communication Dysfunction in Primary Progressive Aphasia
In: Brain Sciences; Volume 11; Issue 12; Pages: 1600 (2021)
Abstract: Mounting evidence suggests that, in parallel with well-defined changes in language, primary progressive aphasia (PPA) syndromes display co-occurring social cognitive impairments. Here, we explored multidimensional profiles of carer-rated social communication using the La Trobe Communication Questionnaire (LCQ) in 11 semantic dementia (SD), 12 logopenic progressive aphasia (LPA) and 9 progressive non-fluent aphasia (PNFA) cases and contrasted their performance with 19 Alzheimer’s disease (AD) cases, 26 behavioural variant frontotemporal dementia (bvFTD) cases and 31 healthy older controls. Relative to the controls, the majority of patient groups displayed significant overall social communication difficulties, with common and unique profiles of impairment evident on the LCQ subscales. Correlation analyses revealed a differential impact of social communication disturbances on functional outcomes in patient and carer well-being, most pronounced for SD and bvFTD. Finally, voxel-based morphometry analyses based on a structural brain MRI pointed to the degradation of a distributed brain network in mediating social communication dysfunction in dementia. Our findings suggest that social communication difficulties are an important feature of PPA, with significant implications for patient function and carer well-being. The origins of these changes are likely to be multifactorial, reflecting the breakdown of fronto-thalamic brain circuits specialised in the integration of complex information.
Keyword: Alzheimer’s disease; frontal lobe; frontotemporal dementia; language; social cognition; thalamus
URL: https://doi.org/10.3390/brainsci11121600
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20
Semantic Variant Primary Progressive Aphasia: Practical Recommendations for Treatment from 20 Years of Behavioural Research
In: Brain Sciences ; Volume 11 ; Issue 12 (2021)
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