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Cognitive control and its impact on recovery from aphasic stroke
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In: BRAIN , 137 pp. 242-254. (2014) (2014)
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| 2 |
Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia
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Meinzer, M; Mohammadi, S; Kugel, H; Schiffbauer, H; Floel, A; Albers, J; Kramer, K; Menke, R; Baumgartner, A; Knecht, S; Breitenstein, C; Deppe, M
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In: NEUROIMAGE , 53 (1) 283 - 290. (2010) (2010)
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Abstract:
Aphasia after middle cerebral artery (MCA) stroke shows highly variable degrees of recovery. One possible explanation may be offered by the variability of the occlusion location. Branches from the proximal portion of the MCA often supply the mesial temporal lobe including parts of the hippocampus, a structure known to be involved in language learning. Therefore, we assessed whether language recovery in chronic aphasia is dependent on the proximity of the MCA infarct and correlated with the integrity of the hippocampus and its surrounding white matter. Language reacquisition capability was determined after 2 weeks of intensive language therapy and 8 months after treatment in ten chronic aphasia patients. Proximity of MCA occlusion relative to the internal carotid artery was determined by magnetic resonance imaging (MRI) based on the most proximal anatomical region infarcted. Structural damage to the hippocampus was assessed by MRI-based volumetry, regional microstructural integrity of hippocampus adjacent white matter by fractional anisotropy. Language learning success for trained materials was correlated with the proximity of MCA occlusion, microstructural integrity of the left hippocampus and its surrounding white matter, but not with lesion size, overall microstructural brain integrity and a control region outside of the MCA territory. No correlations were found for untrained language materials, underlining the specificity of our results for training-induced recovery. Our results suggest that intensive language therapy success in chronic aphasia after MCA stroke is critically dependent on damage to the hippocampus and its surrounding structures. (C) 2010 Elsevier Inc. All rights reserved.
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Keyword:
ACTIVATION; BRAIN; DIFFUSION; MEDIAL TEMPORAL-LOBE; MODEL; MRI; NAMING THERAPY; RECOVERY; RECRUITMENT; STROKE
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URL: http://discovery.ucl.ac.uk/120704/
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| 3 |
Expertise with Artificial Nonspeech Sounds Recruits Speech-Sensitive Cortical Regions
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In: J NEUROSCI , 29 (16) 5234 - 5239. (2009) (2009)
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| 4 |
Reorganization of verbal and nonverbal memory in temporal lobe epilepsy due to unilateral hippocampal sclerosis
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In: EPILEPSIA , 48 (8) 1512 - 1525. (2007) (2007)
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| 5 |
Dissociating speech perception and comprehension at reduced levels of awareness
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In: P NATL ACAD SCI USA , 104 (41) 16032 - 16037. (2007) (2007)
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| 6 |
Brain regions essential for improved lexical access in an aged aphasic patient: a case report
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| 7 |
Reading skills after left anterior temporal lobe resection: an fMRI study
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In: BRAIN , 128 1377 - 1385. (2005) (2005)
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| 8 |
The neural mechanisms of speech comprehension: fMRI studies of semantic ambiguity
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In: CEREB CORTEX , 15 (8) 1261 - 1269. (2005) (2005)
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| 9 |
The human hippocampus: Cognitive maps or relational memory?
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In: J NEUROSCI , 25 (31) 7254 - 7259. (2005) (2005)
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| 10 |
Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
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In: BRAIN , 127 1229 - 1236. (2004) (2004)
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| 11 |
Variability of fMRI activation during a phonological and semantic language task in healthy subjects
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In: HUM BRAIN MAPP , 23 (3) 140 - 155. (2004) (2004)
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| 12 |
Variability of fMRI activation during a phonological and semantic language task in healthy subjects
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Dual-process model in semantic priming: A functional imaging perspective
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In: NEUROIMAGE , 9 (5) 516 - 525. (1999) (1999)
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| 14 |
A multimodal language region in the ventral visual pathway
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In: NATURE , 394 (6690) 274 - 277. (1998) (1998)
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| 15 |
Verbal working memory components can be selectively influenced by transcranial magnetic stimulation in patients with left temporal lobe epilepsy
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In: NEUROPSYCHOLOGIA , 34 (8) 775 - 783. (1996) (1996)
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