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Hits 12.601 – 12.618 of 12.618
12601 |
Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial
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Arenaza, Lide; Medrano Echeverría, María; Amasene, María; Rodríguez Vigil, Beatriz; Díez, Ignacio; Graña, Manuel; Tobalina, Ignacio; Maiz, Edurne; Arteche, Edurne; Larrarte, Eider; Huybrechts, Inge; Davis, Catherine L.; Ruiz, Jonatan R.; Ortega, Francisco B.; Margareto, Javier; Labayen Goñi, Idoia. - : BioMed Central
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Abstract:
Background: The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes (T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention program, including supervised exercise, on insulin resistance syndrome (IRS) risk in children with a high risk of developing T2D and (2) to identify the profile of microRNA in circulating exosomes and in peripheral blood mononuclear cells in children with a high risk of developing T2D and its response to a multidisciplinary intervention program including exercise. Methods: A total of 84 children, aged 8–12 years, with a high risk of T2D will be included and randomly assigned to control (N = 42) or intervention (N = 42) groups. The control group will receive a family based lifestyle education and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week, 90 min per session including warm-up, moderate to vigorous aerobic activities, and strength exercises). The following measurements will be evaluated at baseline prior to randomization and after the intervention: fasting insulin, glucose and hemoglobin A1c; body composition (dual-energy X-ray absorptiometry); ectopic fat (magnetic resonance imaging); microRNA expression in circulating exosomes and in peripheral blood mononuclear cells (MiSeq; Illumina); cardiorespiratory fitness (cardiopulmonary exercise testing); dietary habits and physical activity (accelerometry). Discussion: Prevention and identification of children with a high risk of developing T2D could help to improve their cardiovascular health and to reduce the comorbidities associated with obesity. ; The current project was supported by the Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R), by “Fondos Estructurales de la Unión Europea (FEDER), Una manera de hacer Europa.” and by the University of the Basque Country (GIU14/21). This work was also supported by grants from Spanish Ministry of Economy and Competitiveness (RYC-2010-05957, RYC-2011-09011), Spanish Ministry of Education, Culture and Sports (FPU14/ 03329) and by the Education, Linguistic Policy and Culture Department of the Government of the Basque Country (PRE_2016_1_0057).
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Keyword:
Children; Ectopic fat; Exercise; Family based lifestyle intervention program; miRNA; Type-2 diabetes
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URL: https://doi.org/10.1186/s13063-017-2117-y https://hdl.handle.net/2454/30881
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12602 |
Hepatic fat content and bone mineral density in children with overweight/obesity
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12603 |
Investigating negotiation of meaning in EFL children with very low levels of proficiency
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12604 |
A matter of age: negotiation for meaning in child and adult interactions
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12605 |
Crosslinguistic influence differences in the oral production of young and adult EFL learners
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12606 |
Associations between the adherence to the Mediterranean diet and cardiorespiratory fitness with total and central obesity in preschool children: the PREFIT project
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12607 |
Influence of physical activity on bone mineral content and density in overweight and obese children with low adherence to the Mediterranean dietary pattern
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12608 |
Ahozko kontaketa testuak bigarren hizkuntzaren ikaskuntzan murgiltze prozesuan
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12609 |
Miss Woodward addresses the English Association of Queensland (Brisbane Branch) on 'The Child in Literature: The Child in poetry written for children', 26 Jun 1979
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12610 |
John Radford addresses the English Association of Queensland (Brisbane Branch) on 'The Child in Literature: The Child in Shakespeare', 26 Jun 1979
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12611 |
Mrs Draper addresses the English Association of Queensland (Brisbane Branch) on 'The Child in Literature: The Child in Dickens', 26 Jun 1979
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12612 |
Mrs Thorogood addresses the English Association of Queensland (Brisbane Branch) on 'The Child in Literature: The Child in Dylan Thomas’s writings', 26 Jun 1979
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12613 |
The development of a brief Functional Magnetic Resonance Imaging test battery for neurofunctional investigation of language, memory encoding and motor function in normal children
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12614 |
Female students at Japanese Language School, Portland, ca. 1929
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In: University of Washington Libraries. Special Collections Division. ; Frank Fukuda Photograph and Ephemera Collection. PH Coll 128
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12615 |
Lucille Engdahl working with deaf children, University of Washington Speech Clinic, Seattle, 1939
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In: Museum of History & Industry, Seattle (MOHAI) ; Seattle Post-Intelligencer Collection
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12616 |
No. 23 Annual report of W. J. Shipley, school-teacher, Siletz agency
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In: Report of the Commissioner of Indian Affairs, Made to the Secretary of the Interior, for the Year 1869, p. 173-175 ; University of Washington Libraries
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12617 |
Report of school principal at Puyallup agency
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In: Annual Report of the Commissioner of Indian Affairs to the Secretary of the Interior for the Year 1882, p. 163-164 ; University of Washington Libraries
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12618 |
Medidas antropométricas orofaciais de crianças segundo o tipo facial
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In: Revista CEFAC, Vol 19, Iss 1, Pp 63-68
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