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Maternal Thiamine Supplementation Promotes Infants’ Language Processing at 24 Weeks
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Baldwin, Dare A; Measelle, Jeffrey; Gallivan, Lauren; Sanchirico, Anna; Weinstein, Netanel; Kroeun, Hou; Chea, Mary; Sophonneary, Prak; Green, Tim; Wieringa, Frank; Whitfield, Kyly
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In: Curr Dev Nutr (2021)
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Abstract:
OBJECTIVES: In 2005, researchers observed a link between infants’ access to thiamine (vitamin B1) and their subsequent language functioning: infants fed formula that inadvertently lacked thiamine later displayed significant delays in language and motor development. In the context of a double-blind, randomized, controlled trial, the present research provided the first experimental test of a relationship between early life thiamine exposure and infants’ early language processing. METHODS: 335 lactating mothers were randomly assigned to receive capsules containing either 0, 1.2, 2.4, or 10 mg of thiamine daily, from 2 weeks postpartum until infants were 24 weeks. We assessed the integrity of 24-week-old infants’ developing system for language processing by measuring the extent to which they displayed attentional enhancement in response to infant-directed speech (IDS) relative to adult-directed speech (ADS). Such IDS-related attentional enhancement implies that infants can differentiate IDS from ADS, which requires underlying skills for analysis of the complex stream of sound that human speech embodies. Of the 335 infants in the study, analyzable data for the IDS preference task were available for 251. RESULTS: As predicted, a greater-than-chance percentage of all infants displayed enhanced attention to IDS relative to ADS, replicating prior research (one-sample t(250) = 3.06, P = 0.002). The magnitude of the IDS-elicited attentional-enhancement increased significantly in relation to the thiamine dose that lactating mothers received (beta-weight 0.007, t = 2.57, P = 0.011). Notably, however, when supplementation groups were examined separately, only infants whose mothers received the 10 mg daily supplement displayed a statistically significant IDS-related attentional enhancement (10 mg group: one-sample t(63) = 4.14, P = 0.000; all other groups t’s < 1.41, P’s > 0.16). CONCLUSIONS: Taken together, these findings confirm a link between infants’ post-natal access to thiamine and their language processing facility at 24 weeks. The findings both showcase the value of the IDS preference task for monitoring the integrity of infants’ language processing, and underscore the importance of adequate thiamine for ensuring infants’ optimal language development. FUNDING SOURCES: Bill & Melinda Gates Foundation and the New York Academy of Sciences.
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Keyword:
Neuroscience/Nutrition and the Brain
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181331/
https://doi.org/10.1093/cdn/nzab049_005
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Where arithmetic and phonology meet: The meta-analytic convergence of arithmetic and phonological processing in the brain
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| 8 |
Особенности применения диффузной оптической томографии в нейрообразовании
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СИТНИКОВА М.А.. - : Федеральное государственное автономное образовательное учреждение высшего образования «Белгородский государственный национальный исследовательский университет», 2016
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МІЖПІВКУЛЬНА АСИМЕТРІЯ МОЗКУ ЯК ПСИХОФІЗІОЛОГІЧНА ОСНОВА ІНДИВІДУАЛЬНО-ТИПОЛОГІЧНИХ ОСОБЛИВОСТЕЙ ФОРМУВАННЯ ПОЧУТТЯ ГУМОРУ
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ШПОРТУН О.М.. - : ГУ «Днепропетровская медицинская академия МЗ Украины», 2016
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
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In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 12, iss 3 (2016)
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Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 12, iss 3 (2016)
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Hierarchies of Brain and Being: Abraham Maslow and the Origins of The Hierarchy of Needs in German Brain Science
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Poster Presentation: Abraham Maslow and the Origins of The Hierarchy of Needs in German Brain Science
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НЕЙРОЛИНГВИСТИЧЕСКИЙ АСПЕКТ ПРОБЛЕМЫ ПРЕОДОЛЕНИЯ ДИСГРАММАТИЗМА У ДЕТЕЙ С ПОСЛЕДСТВИЯМИ ЛОКАЛЬНЫХ ПОРАЖЕНИЙ МОЗГА
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Когнитивные стили мышления и стратегии дефинирования в онтогенезе: психолингвистический аспект
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САМИГУЛИНА ФАНИРА ГАБДУЛЛОВНА. - : Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования «Уральский государственный педагогический университет», 2015
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Lexical is as lexical does: computational approaches to lexical representation
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Dynamic information processing states revealed through neurocognitive models of object semantics
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Change Your Language, Change Your Lives: What Adults Can Say Differently Today to Change the Brains of Tomorrow
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In: National Youth Advocacy and Resilience Conference (2015)
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