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Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
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In: ISSN: 1359-4184 ; EISSN: 1476-5578 ; Molecular Psychiatry ; https://hal.archives-ouvertes.fr/hal-02976104 ; Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-00898-x⟩ (2020)
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In Search of Cognitive Promotive and Protective Factors for Word Reading
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In: Sci Stud Read (2020)
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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In: ISSN: 2158-3188 ; EISSN: 2158-3188 ; Translational Psychiatry ; https://hal.archives-ouvertes.fr/hal-02158502 ; Translational Psychiatry, Nature Pub. Group, 2019, 9, pp.77. ⟨10.1038/s41398-019-0402-0⟩ (2019)
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia ...
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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In: Translational Psychiatry, 9 (1) (2019)
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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Examining the Influence of Perceived Stress on Developmental Change in Memory and Perceptual Speed for Adopted and Non-Adopted Individuals
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Genome-wide screening for DNA variants associated with reading and language traits
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Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ
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Eicher, John D.; Powers, Natalie R.; Miller, Laura L.; Mueller, Kathryn L.; Mascheretti, Sara; Marino, Cecilia; Willcutt, Erik G.; DeFries, John C.; Olson, Richard K.; Smith, Shelley D.; Pennington, Bruce F.; Tomblin, J. Bruce; Ring, Susan M.; Gruen, Jeffrey R.. - : Springer Berlin Heidelberg, 2014
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Abstract:
Reading disability (RD) and language impairment (LI) are common neurodevelopmental disorders with moderately strong genetic components and lifelong implications. RD and LI are marked by unexpected difficulty acquiring and processing written and verbal language, respectively, despite adequate opportunity and instruction. RD and LI—and their associated deficits—are complex, multifactorial, and often comorbid. Genetic studies have repeatedly implicated the DYX2 locus, specifically the genes DCDC2 and KIAA0319, in RD, with recent studies suggesting they also influence LI, verbal language, and cognition. Here, we characterize the relationship of the DYX2 locus with RD, LI, and IQ. To accomplish this, we developed a marker panel densely covering the 1.4 Mb DYX2 locus and assessed association with reading, language, and IQ measures in subjects from the Avon Longitudinal Study of Parents and Children. We then replicated associations in three independent, disorder-selected cohorts. As expected, there were associations with known RD risk genes KIAA0319 and DCDC2. In addition, we implicated markers in or near other DYX2 genes, including TDP2, ACOT13, C6orf62, FAM65B, and CMAHP. However, the LD structure of the locus suggests that associations within TDP2, ACOT13, and C6orf62 are capturing a previously reported risk variant in KIAA0319. Our results further substantiate the candidacy of KIAA0319 and DCDC2 as major effector genes in DYX2, while proposing FAM65B and CMAHP as new DYX2 candidate genes. Association of DYX2 with multiple neurobehavioral traits suggests risk variants have functional consequences affecting multiple neurological processes. Future studies should dissect these functional, possibly interactive relationships of DYX2 candidate genes.
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Keyword:
Original Investigation
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URL: http://www.ncbi.nlm.nih.gov/pubmed/24509779
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053598
https://doi.org/10.1007/s00439-014-1427-3
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Genetic and Environmental Etiologies of the Longitudinal Relations between Pre-reading Skills and Reading
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DNA Evidence for Strong Genome-Wide Pleiotropy of Cognitive and Learning Abilities
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A multivariate twin study of early literacy in Japanese Kana
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DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities
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Predicting Word Reading and Comprehension with Executive Function and Speed Measures Across Development: A Latent Variable Analysis
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Choice of Reading Comprehension Test Influences the Outcomes of Genetic Analyses
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