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Developing, monitoring, and reporting of fidelity in aphasia trials: Core recommendations from the Collaboration of Aphasia Trialists (CATs) Trials for Aphasia Panel
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An umbrella review of aphasia intervention description in research: The AsPIRE project
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In: Research outputs 2014 to 2021 (2022)
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Dosage, intensity, and frequency of language therapy for aphasia: a systematic review–based, individual participant data network meta-analysis
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Brady, MC; Ali, M; VandenBerg, K; Williams, LJ; Williams, LR; Abo, M; Becker, F; Bowen, A; Brandenburg, C; Breitenstein, C; Bruehl, S; Copland, DA; Cranfill, TB; di Pietro-Bachmann, M; Enderby, P; Fillingham, J; Galli, FL; Gandolfi, M; Glize, B; Godecke, E; Hawkins, N; Hilari, K; Hinckley, J; Horton, S; Howard, D; Jaecks, P; Jefferies, E; Jesus, LMT; Kambanaros, M; Kang, EK; Khedr, EM; Kong, AP-H; Kukkonen, T; Laganaro, M; Ralph, MAL; Laska, AC; Leemann, B; Leff, AP; Lima, RR; Lorenz, A; MacWhinney, B; Marshall, RS; Mattioli, F; Maviş, İ; Meinzer, M; Nilipour, R; Noé, E; Paik, N-J; Palmer, R; Papathanasiou, I; Patricio, B; Martins, IP; Price, C; Jakovac, TP; Rochon, E; Rose, ML; Rosso, C; Rubi-Fessen, I; Ruiter, MB; Snell, C; Stahl, B; Szaflarski, JP; Thomas, SA; van de Sandt-Koenderman, M; van der Meulen, I; Visch-Brink, E; Worrall, L; Wright, HH. - : Ovid Technologies (Wolters Kluwer Health), 2022
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Abstract:
Background and Purpose: Optimizing speech and language therapy (SLT) regimens for maximal aphasia recovery is a clinical research priority. We examined associations between SLT intensity (hours/week), dosage (total hours), frequency (days/week), duration (weeks), delivery (face to face, computer supported, individual tailoring, and home practice), content, and language outcomes for people with aphasia. Methods: Databases including MEDLINE and Embase were searched (inception to September 2015). Published, unpublished, and emerging trials including SLT and ≥10 individual participant data on aphasia, language outcomes, and time post-onset were selected. Patient-level data on stroke, language, SLT, and trial risk of bias were independently extracted. Outcome measurement scores were standardized. A statistical inferencing, one-stage, random effects, network meta-analysis approach filtered individual participant data into an optimal model examining SLT regimen for overall language, auditory comprehension, naming, and functional communication pre-post intervention gains, adjusting for a priori–defined covariates (age, sex, time poststroke, and baseline aphasia severity), reporting estimates of mean change scores (95% CI). Results: Data from 959 individual participant data (25 trials) were included. Greatest gains in overall language and comprehension were associated with >20 to 50 hours SLT dosage (18.37 [10.58–26.16] Western Aphasia Battery–Aphasia Quotient; 5.23 [1.51–8.95] Aachen Aphasia Test–Token Test). Greatest clinical overall language, functional communication, and comprehension gains were associated with 2 to 4 and 9+ SLT hours/week. Greatest clinical gains were associated with frequent SLT for overall language, functional communication (3–5+ days/week), and comprehension (4–5 days/week). Evidence of comprehension gains was absent for SLT ≤20 hours, <3 hours/week, and ≤3 days/week. Mixed receptive-expressive therapy, functionally tailored, with prescribed home practice was associated with the greatest overall gains. Relative variance was <30%. Risk of trial bias was low to moderate; low for meta-biases. Conclusions: Greatest language recovery was associated with frequent, functionally tailored, receptive-expressive SLT, with prescribed home practice at a greater intensity and duration than reports of usual clinical services internationally. These exploratory findings suggest critical therapeutic ranges, informing hypothesis-testing trials and tailoring of clinical services. Registration: URL: https://www.crd.york.ac.uk/PROSPERO/; Unique identifier: CRD42018110947.
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URL: https://eprints.whiterose.ac.uk/184302/
https://eprints.whiterose.ac.uk/184302/1/STROKEAHA.121.035216%20%281%29.pdf
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Protocol for the development of the international population registry for aphasia after stroke (I-PRAISE)
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An aphasia research agenda–a consensus statement from the collaboration of aphasia trialists
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Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke
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Dosage, Intensity, and Frequency of Language Therapy for Aphasia: A Systematic Review-Based, Individual Participant Data Network Meta-Analysis
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An Umbrella Review of Aphasia Intervention descriPtion In Research: the AsPIRE project
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Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke
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An aphasia research agenda – a consensus statement from the collaboration of aphasia trialists
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Predictors of poststroke aphasia recovery: a systematic review-informed individual participant data meta-analysis
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A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study ...
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Communicating simply, but not too simply: Reporting of participants and speech and language interventions for aphasia after stroke
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RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
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RELEASE : a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
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RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
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In: Aphasiology, 2019 (2019)
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Tidier descriptions of speech and language therapy interventions for people with aphasia; consensus from the release collaboration
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Tidier descriptions of speech and language therapy interventions for people with aphasia; consensus from the RELEASE collaboration
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Constraint-induced aphasia therapy (CIAT): a randomised controlled trial in very early stroke rehabilitation
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