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Supplementary material from " DCDC2 READ1 regulatory element: how temporal processing differences may shape language" ...
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Supplementary material from " DCDC2 READ1 regulatory element: how temporal processing differences may shape language" ...
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Data from: DCDC2 READ1 regulatory element: how temporal processing differences may shape language ...
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Supplementary Materials for DCDC2 READ1 regulatory element: how temporal processing differences may shape language ...
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Supplementary Materials for DCDC2 READ1 regulatory element: how temporal processing differences may shape language ...
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DCDC2 READ1 regulatory element: how temporal processing differences may shape language
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In: Proc Biol Sci (2020)
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The temporal dynamics of first and second language processing: ERPs to spoken words in Mandarin-English bilinguals
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In: Neuropsychologia (2020)
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The temporal dynamics of first and second language processing: ERPs to spoken words in Mandarin-English bilinguals
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In: Brain and Mind Institute Researchers' Publications (2020)
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Achievement attributions are associated with specific rather than general learning delays
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In: Learn Individ Differ (2018)
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A molecular-genetic and imaging-genetic approach to specific comprehension difficulties in children
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Reading-Related Causal Attributions for Success and Failure: Dynamic Links With Reading Skill
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Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders
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Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ
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Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language
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Abstract:
Language impairment (LI) and reading disability (RD) are common pediatric neurobehavioral disorders that frequently co-occur, suggesting they share etiological determinants. Recently, our group identified prenatal nicotine exposure as a factor for RD and poor reading performance. Using smoking questionnaire and language data from the Avon Longitudinal Study of Parents and Children, we first determined if this risk could be expanded to other communication disorders by evaluating whether prenatal nicotine exposure increases risk for LI and poor performance on language tasks. Prenatal nicotine exposure increased LI risk (OR = 1.60; p = 0.0305) in a dose-response fashion with low (OR = 1.25; p = 0.1202) and high (OR = 3.84; p = 0.0002) exposures. Next, hypothesizing that the effects of prenatal nicotine may also implicate genes that function in nicotine related pathways, we determined whether known nicotine dependence (ND) genes associate with performance on language tasks. We assessed the association of 33 variants previously implicated in ND with LI and language abilities, finding association between ANKK1/DRD2 and performance on language tasks (p≤0.0003). The associations of markers within ANKK1 were replicated in a separate LI case-control cohort (p<0.05). Our results show that smoking during pregnancy increases the risk for LI and poor performance on language tasks and that ANKK1/DRD2 contributes to language performance. More precisely, these findings suggest that prenatal environmental factors influence in utero development of neural circuits vital to language. Our association of ANKK1/DRD2 further implicates the role of nicotine-related pathways and dopamine signaling in language processing, particularly in comprehension and phonological memory. ; Version of Record
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Keyword:
Behavioral Neuroscience; Biology; Clinical Research Design; Complex Traits; Developmental and Pediatric Neurology; Genetic Association Studies; Genetics; Heredity; Human Genetics; Medicine; Neurology; Neuropsychology; Neuroscience; Pediatrics; Survey Research
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URL: https://doi.org/10.1371/journal.pone.0063762 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181191
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Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language
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Pleiotropic Effects of DCDC2 and DYX1C1 Genes on Language and Mathematics Traits in Nuclear Families of Developmental Dyslexia
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