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Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes
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In: Neurobiol Aging (2022)
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Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. ...
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Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool ...
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Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes ...
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Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool
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In: Front Aging Neurosci (2021)
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes
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Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool
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Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool.
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In: essn: 1663-4365 ; nlmid: 101525824 (2021)
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes ...
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes ...
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes
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Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes
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In: Brain (2020)
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes
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In: J Neurol (2020)
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[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia
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Artificial grammar learning in vascular and progressive non-fluent aphasias
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The Effect of Aging on the Neural Correlates of Phonological Word Retrieval
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A comparison of VLSM and VBM in a cohort of patients with post-stroke aphasia☆
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The neural correlates of inner speech defined by voxel-based lesion-symptom mapping
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The neural correlates of inner speech defined by voxel-based lesion–symptom mapping
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Abstract:
The neural correlates of inner speech have been investigated previously using functional imaging. However, methodological and other limitations have so far precluded a clear description of the neural anatomy of inner speech and its relation to overt speech. Specifically, studies that examine only inner speech often fail to control for subjects’ behaviour in the scanner and therefore cannot determine the relation between inner and overt speech. Functional imaging studies comparing inner and overt speech have not produced replicable results and some have similar methodological caveats as studies looking only at inner speech. Lesion analysis can avoid the methodological pitfalls associated with using inner and overt speech in functional imaging studies, while at the same time providing important data about the neural correlates essential for the specific function. Despite its advantages, a study of the neural correlates of inner speech using lesion analysis has not been carried out before. In this study, 17 patients with chronic post-stroke aphasia performed inner speech tasks (rhyme and homophone judgements), and overt speech tasks (reading aloud). The relationship between brain structure and language ability was studied using voxel-based lesion–symptom mapping. This showed that inner speech abilities were affected by lesions to the left pars opercularis in the inferior frontal gyrus and to the white matter adjacent to the left supramarginal gyrus, over and above overt speech production and working memory. These results suggest that inner speech cannot be assumed to be simply overt speech without a motor component. It also suggests that the use of overt speech to understand inner speech and vice versa might result in misleading conclusions, both in imaging studies and clinical practice.
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Keyword:
Original Articles
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187541 https://doi.org/10.1093/brain/awr232 http://www.ncbi.nlm.nih.gov/pubmed/21975590
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