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Bilingual experience and resting-state brain connectivity: Impacts of L2 age of acquisition and social diversity of language use on control networks ...
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Bilingual Experience and Resting-State Brain Connectivity: Impacts of L2 Age of Acquisition and Social Diversity of Language Use on Control Networks
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Intrinsic Functional Connectivity in the Adult Brain and Success in Second-Language Learning
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Mapping the unconscious maintenance of a lost first language
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Neuro-cognitive
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O'Neil, Sharon H.; Azoff, Jaye; Buranahirun, Cathliyn; Dhall, Girish; Panigrahy, Ashok; Borchert, Mark; Khatua, Soumen; Ji, Lingyun; Sposto, Richard; Finlay, Jonathan; Gong, Xing; Schwartz, Philip; Linskey, Mark; Bota, Daniela A.; Wefel, Jeffrey S.; Patwardhan, Surabhi Y.; Strange, Crystal; Emily, Ferreira; Celine, Amiez; Penelope, Kostopoulos; Anne-Sophie, Champod; Rolando, Del Maestro; Michael, Petrides; Correa, Denise D.; Shi, Weiji; Abrey, Lauren; DeAngelis, Lisa; Thaler, Howard; Habets, Esther J.; Walchenbach, Rob; Kloet, Alfred; Zwinkels, Hanneke; Klein, Martin; Vecht, Charles J.; Taphoorn, Martin J.; Ambachtsheer, Nina; van Nieuwenhuizen, David; Heimans, Jan J.; Reijneveld, Jaap C.; Peerdeman, Saskia M.; Lagemaat, Corine; Peters, Katherine B.; Reardon, David A.; Vredenburgh, James J.; Desjardins, Annick; Friedman, Henry S.; Driever, Pablo Hernaiz; Koustenis, Elisabeth; Henze, Guenter; De Sonneville, Leo; Rueckriegel, Stefan M.; Mok, Kelvin; Klein, Denise; Del Maestro, Rolando; Petrecca, Kevin; Olivier, André; Schanker, Benjamin D.; Curry, William T.; Edelstein, Kim; Spiegler, Brenda J.; Fung, Sharon; Panzarella, Tony; Hodgson, David C.; Mabbott, Donald J.; Laperriere, Normand; Tabori, Uri; Bouffet, Eric; Mason, Warren P.. - : Oxford University Press, 2010
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STUDY PURPOSE: Evaluate neurocognitive outcomes following a treatment strategy of chemotherapy followed by reduced-dose and volume irradiation for primary CNS germinoma. METHODS: Neuropsychological evaluations including measures of intellectual functioning, working memory, processing speed, memory, executive functioning, and social-emotional functioning were analyzed for all patients (N = 19) with histologically-diagnosed CNS germinoma treated at our institution between 2003 and 2008. All 19 patients underwent at least one neuropsychological evaluation and 10 patients had two evaluations, generating a total of 29 test batteries at a mean of 2.6 years from diagnosis. Linear mixed effect models were used to determine whether there was a significant change in the test scores over time. The association between test scores and patient or disease characteristics (tumor location, patient age at diagnosis, hydrocephalus at presentation, and English or other primary language) was examined using linear mixed effect models by adjusting for the effect of time. RESULTS: The 19 patients performed as a group in the average range on all neurocognitive measures. No decline over time was indicated. An improvement over time was indicated for nonverbal reasoning and processing speed. No significant differences were found by tumor location, patient age at diagnosis, or hydrocephalus at presentation. Verbal intellectual functioning was significantly lower for bilingual patients, even though all patients except one were English-dominant; that one patient was assessed in Spanish. CONCLUSIONS: For pediatric and adolescent patients with newly diagnosed CNS germinoma, modest chemotherapy followed by reduced-dose ventricular field irradiation with simultaneous integrated boost to the primary site, is associated with preservation of neurocognitive functioning. Improvement over time in visually-based nonverbal reasoning and processing speed likely reflects resolving Parinaud Syndrome for subjects with pineal-region tumors and resolving visual field deficits for those with suprasellar tumors. English language measures likely underestimate verbal intelligence for bilingual patients, even when English is the dominant language.
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URL: http://neuro-oncology.oxfordjournals.org/cgi/content/short/12/suppl_4/iv58 https://doi.org/10.1093/neuonc/noq116.s7
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Bilingual brain organization: a functional magnetic resonance adaptation study
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