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Functional Magnetic Resonance Imaging of Language Following Constraint-Induced Aphasia Therapy Primed with Intermittent Theta Burst Stimulation in 13 Patients with Post-Stroke Aphasia
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In: Med Sci Monit (2021)
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Reproducibility of Brain Responses: High for Speech Perception, Low for Reading Difficulties
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In: Scientific Reports (2019)
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Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia Therapy
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Lesion-behavior mapping of treatment effects on naming ability in chronic post-stroke aphasia ...
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Effects of a combined rTMS and CIAT intervention on patients with chronic post-stroke aphasia ...
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The canonical semantic network supports residual language function in chronic post-stroke aphasia ...
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Damage to white matter bottlenecks contributes to language impairments after left hemispheric stroke ...
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Parallel ICA reveals linked patterns of structural damage and fMRI language task activation in chronic post-stroke aphasia ...
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The canonical semantic network supports residual language function in chronic post-stroke aphasia
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Arcuate fasciculus asymmetry has a hand in language function but not handedness
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Abstract:
The importance of relationships between handedness, language lateralization and localization, and white matter tracts for language performance are unclear. The goal of the study was to investigate these relationships by examining arcuate fasciculus (AF) structural asymmetry (DTI) and functional asymmetry (fMRI) in language circuits, handedness, and linguistic performance. A large sample of right-handed (n=158) and atypical-handed (n=82) healthy adults underwent DTI at 3T to assess number of streamlines and fractional anisotropy (FA) of the AF, and language fMRI. Language functions were assessed using standard tests of vocabulary, naming, verbal fluency and complex ideation. Laterality indices (LIs) illustrated degree of asymmetry and lateralization patterns for the AF (streamlines and FA) and verb generation fMRI. Both handedness groups showed leftward lateralization bias for streamline and fMRI LIs and symmetry for FA LI. The proportion of subjects with left, right or symmetric lateralization were similar between groups if based on AF LIs, but differed if based on fMRI LIs (p=0.0016). Degree of right-handedness was not associated with AF lateralization, but was associated with fMRI language lateralization (p=0.0014). FA LI was not associated with performance on language assessments, but streamline LI was associated with better vocabulary and complex ideation performance in atypical-handed subjects (p=0.022 and p=0.0098, respectively), and better semantic fluency in right-handed subjects (p=0.047); however, these did not survive multiple comparisons correction. We provide evidence that AF asymmetry is independent of hand preference, and while degree of right-handedness is associated with hemispheric language lateralization, the majority of atypical-handed individuals are left-lateralized for language.
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URL: https://doi.org/10.1002/hbm.23241 http://www.ncbi.nlm.nih.gov/pubmed/27144738 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988400/
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Remediation Effects on N170 and P300 in Children with Developmental Dyslexia
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