1 |
Lesions that do or do not impair digit span: a study of 816 stroke survivors
|
|
Geva, Sharon; Truneh, Teodros; Seghier, Mohamed L; Hope, Thomas M H; Leff, Alex P; Crinion, Jennifer T; Gajardo-Vidal, Andrea; Lorca-Puls, Diego L; Green, David W; Price, Cathy J
|
|
In: Brain Commun (2021)
|
|
Abstract:
Prior studies have reported inconsistency in the lesion sites associated with verbal short-term memory impairments. Here we asked: How many different lesion sites can account for selective impairments in verbal short-term memory that persist over time, and how consistently do these lesion sites impair verbal short-term memory? We assessed verbal short-term memory impairments using a forward digit span task from the Comprehensive Aphasia Test. First, we identified the incidence of digit span impairments in a sample of 816 stroke survivors (541 males/275 females; age at stroke onset 56 ± 13 years; time post-stroke 4.4 ± 5.2 years). Second, we studied the lesion sites in a subgroup of these patients (n = 39) with left hemisphere damage and selective digit span impairment—defined as impaired digit span with unimpaired spoken picture naming and spoken word comprehension (tests of speech production and speech perception, respectively). Third, we examined how often these lesion sites were observed in patients who either had no digit span impairments or digit span impairments that co-occurred with difficulties in speech perception and/or production tasks. Digit span impairments were observed in 222/816 patients. Almost all (199/222 = 90%) had left hemisphere damage to five small regions in basal ganglia and/or temporo-parietal areas. Even complete damage to one or more of these five regions was not consistently associated with persistent digit span impairment. However, when the same regions were spared, only 5% (23/455) presented with digit span impairments. These data suggest that verbal short-term memory impairments are most consistently associated with damage to left temporo-parietal and basal ganglia structures. Sparing of these regions very rarely results in persistently poor verbal short-term memory. These findings have clinical implications for predicting recovery of verbal short-term memory after stroke.
|
|
Keyword:
Original Article
|
|
URL: https://doi.org/10.1093/braincomms/fcab031 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066865/
|
|
BASE
|
|
Hide details
|
|
2 |
Damage to Broca’s area does not contribute to long-term speech production outcome after stroke
|
|
|
|
In: Brain (2021)
|
|
BASE
|
|
Show details
|
|
3 |
A Data-Based Approach for Selecting Pre- and Intra-Operative Language Mapping Tasks
|
|
|
|
In: Front Neurosci (2021)
|
|
BASE
|
|
Show details
|
|
4 |
Right hemisphere structural adaptation and changing language skills years after left hemisphere stroke
|
|
|
|
BASE
|
|
Show details
|
|
5 |
Language Control and Lexical Competition in Bilinguals: An Event-Related fMRI Study
|
|
|
|
BASE
|
|
Show details
|
|
6 |
Dissociating the semantic function of two neighbouring subregions in the left lateral anterior temporal lobe
|
|
|
|
BASE
|
|
Show details
|
|
7 |
A Trade-Off between Somatosensory and Auditory Related Brain Activity during Object Naming But Not Reading
|
|
|
|
BASE
|
|
Show details
|
|
8 |
Comparing language outcomes in monolingual and bilingual stroke patients
|
|
|
|
BASE
|
|
Show details
|
|
9 |
Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana
|
|
|
|
BASE
|
|
Show details
|
|
10 |
Dissecting the functional anatomy of auditory word repetition
|
|
|
|
BASE
|
|
Show details
|
|
11 |
The Importance of Premotor Cortex for Supporting Speech Production after Left Capsular-Putaminal Damage
|
|
|
|
BASE
|
|
Show details
|
|
12 |
Sensory-to-motor integration during auditory repetition: a combined fMRI and lesion study
|
|
|
|
BASE
|
|
Show details
|
|
14 |
The Angular Gyrus: Multiple Functions and Multiple Subdivisions
|
|
|
|
BASE
|
|
Show details
|
|
15 |
Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana
|
|
|
|
BASE
|
|
Show details
|
|
16 |
Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana
|
|
|
|
BASE
|
|
Show details
|
|
17 |
Auditory–motor interactions for the production of native and non-native speech
|
|
|
|
BASE
|
|
Show details
|
|
19 |
Where, When and Why Brain Activation Differs for Bilinguals and Monolinguals during Picture Naming and Reading Aloud
|
|
|
|
BASE
|
|
Show details
|
|
20 |
Where, When and Why Brain Activation Differs for Bilinguals and Monolinguals during Picture Naming and Reading Aloud
|
|
|
|
BASE
|
|
Show details
|
|
|
|