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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 Hits 1 – 20 of 37 1 Lesions that do or do not impair digit span: a study of 816 stroke survivors Geva, Sharon; Truneh, Teodros; Seghier, Mohamed L... In: Brain Commun (2021) BASE Show details 2 Damage to Broca’s area does not contribute to long-term speech production outcome after stroke Gajardo-Vidal, Andrea; Lorca-Puls, Diego L; team, PLORAS; Warner, Holly; Pshdary, Bawan; Crinion, Jennifer T; Leff, Alexander P; Hope, Thomas M H; Geva, Sharon; Seghier, Mohamed L; Green, David W; Bowman, Howard; Price, Cathy J In: Brain (2021) Abstract: Broca’s area in the posterior half of the left inferior frontal gyrus has long been thought to be critical for speech production. The current view is that long-term speech production outcome in patients with Broca’s area damage is best explained by the combination of damage to Broca’s area and neighbouring regions including the underlying white matter, which was also damaged in Paul Broca’s two historic cases. Here, we dissociate the effect of damage to Broca’s area from the effect of damage to surrounding areas by studying long-term speech production outcome in 134 stroke survivors with relatively circumscribed left frontal lobe lesions that spared posterior speech production areas in lateral inferior parietal and superior temporal association cortices. Collectively, these patients had varying degrees of damage to one or more of nine atlas-based grey or white matter regions: Brodmann areas 44 and 45 (together known as Broca’s area), ventral premotor cortex, primary motor cortex, insula, putamen, the anterior segment of the arcuate fasciculus, uncinate fasciculus and frontal aslant tract. Spoken picture description scores from the Comprehensive Aphasia Test were used as the outcome measure. Multiple regression analyses allowed us to tease apart the contribution of other variables influencing speech production abilities such as total lesion volume and time post-stroke. We found that, in our sample of patients with left frontal damage, long-term speech production impairments (lasting beyond 3 months post-stroke) were solely predicted by the degree of damage to white matter, directly above the insula, in the vicinity of the anterior part of the arcuate fasciculus, with no contribution from the degree of damage to Broca’s area (as confirmed with Bayesian statistics). The effect of white matter damage cannot be explained by a disconnection of Broca’s area, because speech production scores were worse after damage to the anterior arcuate fasciculus with relative sparing of Broca’s area than after damage to Broca’s area with relative sparing of the anterior arcuate fasciculus. Our findings provide evidence for three novel conclusions: (i) Broca’s area damage does not contribute to long-term speech production outcome after left frontal lobe strokes; (ii) persistent speech production impairments after damage to the anterior arcuate fasciculus cannot be explained by a disconnection of Broca’s area; and (iii) the prior association between persistent speech production impairments and Broca’s area damage can be explained by co-occurring white matter damage, above the insula, in the vicinity of the anterior part of the arcuate fasciculus. Keyword: Original Articles URL: https://doi.org/10.1093/brain/awaa460 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041045/ http://www.ncbi.nlm.nih.gov/pubmed/33517378 BASE Hide details 3 A Data-Based Approach for Selecting Pre- and Intra-Operative Language Mapping Tasks Ekert, Justyna O.; Kirkman, Matthew A.; Seghier, Mohamed L.... In: Front Neurosci (2021) BASE Show details 4 Right hemisphere structural adaptation and changing language skills years after left hemisphere stroke Hope, Thomas M. H.; Leff, Alex P.; Prejawa, Susan. - : Oxford University Press, 2017 BASE Show details 5 Language Control and Lexical Competition in Bilinguals: An Event-Related fMRI Study Abutalebi, Jubin; Annoni, Jean-Marie; Zimine, Ivan. - 2017 BASE Show details 6 Dissociating the semantic function of two neighbouring subregions in the left lateral anterior temporal lobe Sanjuán, Ana; Hope, Thomas M.H.; Parker Jones, 'Ōiwi. - : Pergamon Press, 2015 BASE Show details 7 A Trade-Off between Somatosensory and Auditory Related Brain Activity during Object Naming But Not Reading Seghier, Mohamed L.; Hope, Thomas M.H.; Prejawa, Susan. - : Society for Neuroscience, 2015 BASE Show details 8 Comparing language outcomes in monolingual and bilingual stroke patients Hope, Thomas M. H.; Parker Jones, ‘Ōiwi; Grogan, Alice. - : Oxford University Press, 2015 BASE Show details 9 Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana Kawabata Duncan, Keith J.; Twomey, Tae; Parker Jones, ‘Ōiwi. - : Oxford University Press, 2014 BASE Show details 10 Dissecting the functional anatomy of auditory word repetition Hope, Thomas M. H.; Prejawa, Susan; Parker Jones, ‘Ōiwi. - : Frontiers Media S.A., 2014 BASE Show details 11 The Importance of Premotor Cortex for Supporting Speech Production after Left Capsular-Putaminal Damage Seghier, Mohamed L.; Bagdasaryan, Juliana; Jung, Dorit E.. - : Society for Neuroscience, 2014 BASE Show details 12 Sensory-to-motor integration during auditory repetition: a combined fMRI and lesion study Parker Jones, ‘Ōiwi; Prejawa, Susan; Hope, Thomas M. H.. - : Frontiers Media S.A., 2014 BASE Show details 13 Dissociating frontal regions that co-lateralize with different ventral occipitotemporal regions during word processing Seghier, Mohamed L.; Price, Cathy J. In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 126 (2013) 2, 133-140 OLC Linguistik Show details 14 The Angular Gyrus: Multiple Functions and Multiple Subdivisions Seghier, Mohamed L.. - : SAGE Publications, 2013 BASE Show details 15 Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana Kawabata Duncan, Keith J.; Twomey, Tae; Parker Jones, Oiwi. - : Oxford University Press, 2013 BASE Show details 16 Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana Kawabata Duncan, Keith J.; Twomey, Tae; Parker Jones, Oiwi. - : Oxford University Press, 2013 BASE Show details 17 Auditory–motor interactions for the production of native and non-native speech Jones, ‘Ōiwi Parker; Seghier, Mohamed L.; Duncan, Keith J. Kawabata. - 2013 BASE Show details 18 Reading without the left ventral occipito-temporal cortex Seghier, Mohamed L.; Neufeld, Nicholas H.; Zeidman, Peter. - : Pergamon Press, 2012 BASE Show details 19 Where, When and Why Brain Activation Differs for Bilinguals and Monolinguals during Picture Naming and Reading Aloud Parker Jones, ‘?iwi; Green, David W.; Grogan, Alice. - 2012 BASE Show details 20 Where, When and Why Brain Activation Differs for Bilinguals and Monolinguals during Picture Naming and Reading Aloud Parker Jones, ‘Oiwi; Green, David W.; Grogan, Alice. - : Oxford University Press, 2012 BASE Show details Page: 1 2

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