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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya; Rankin, Katherine P; Taylor, Jack; Fields, Julie A; Casaletto, Kaitlin B; Hillis, Argye E; Lukic, Sladjana; Gorno-Tempini, Maria Luisa; Heuer, Hilary; Teylan, Merilee A; Kukull, Walter A; Miller, Bruce L; Boeve, Bradley F; Rosen, Howard J; Boxer, Adam L; Kramer, Joel H
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Abstract:
IntroductionThe Frontotemporal Lobar Degeneration Module (FTLD-MOD) includes a neuropsychological battery designed to assess the clinical features of FTLD, although much is unknown about its utility. We investigated FTLD-MOD and Uniform Data Set 3.0 (UDS) language tests for differential diagnosis and disease monitoring.MethodsLinear regressions compared baseline performances in 1655 National Alzheimer's Coordinating Center participants (behavioral variant frontotemporal dementia (bvFTD, n=612), semantic variant primary progressive aphasia (svPPA, n=168), non-fluent/agrammatic variant PPA (nfvPPA, n=168), logopenic variant PPA (lvPPA, n=109), and controls (n=581)). Sample sizes to detect treatment effects were estimated using longitudinal data.ResultsAmong PPAs, the FTLD-MOD language tasks and UDS Multilingual Naming Test accurately discriminated svPPA. Number Span Forward best discriminated lvPPA; Phonemic:Semantic Fluency ratio was excellent for nfvPPA classification. UDS fluency and naming measures required the smallest sample size to detect meaningful change.DiscussionThe FTLD-MOD and UDS differentiated among PPA subtypes. UDS 3.0 measures performed best for longitudinal monitoring.
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Keyword:
Acquired Cognitive Impairment; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Aphasia; Brain Disorders; Clinical Research; clinical trials; Clinical Trials and Supportive Activities; cognition; Dementia; differential diagnosis; endpoints; frontotemporal dementia; Frontotemporal Dementia (FTD); FTLD module; Genetics; longitudinal; Neurodegenerative; neuropsychology; Neurosciences; primary progressive aphasia; Rare Diseases; speech
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URL: https://escholarship.org/uc/item/31v6d3qh
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42 |
Making a Way Out of No Way: An Antideficit Approach to Financial Literacy
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43 |
" 'Sù lo bord' ou quelques poèmes en dialecte nissart du XVIIIe siècle"
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In: XIIIe congrès international de l'AIEO "Occitanie : centres et périphéries" ; https://hal.archives-ouvertes.fr/hal-03568134 ; XIIIe congrès international de l'AIEO "Occitanie : centres et périphéries", Walter Meliga; Giuseppe Noto, Matteo Rivoira, Jul 2021, Cuneo, Italie (2021)
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Détermination et quantification
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In: Grande grammaire du français ; https://hal.archives-ouvertes.fr/hal-03277356 ; Grande grammaire du français, 2021 (2021)
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Bibliothèque numérique et nouveaux usages
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In: Journée EVEILLE Exploration et Valorisation Electroniques des corpus de l'ILLE, journée 2 : Bibliothèques numériques ; https://hal.archives-ouvertes.fr/hal-03229093 ; Journée EVEILLE Exploration et Valorisation Electroniques des corpus de l'ILLE, journée 2 : Bibliothèques numériques, Feb 2021, Mulhouse, France (2021)
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Une métaphonie occitane existe-t-elle ? Interprétation diachronique et synchronique de la diphtongaison conditionnée de l’occitan
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In: XIIIème Congrès de l’Association Internationale d’Études Occitanes ; https://hal.archives-ouvertes.fr/hal-02477619 ; XIIIème Congrès de l’Association Internationale d’Études Occitanes, Matteo Rivoira, Walter Meliga, Giuseppe Noto, Jul 2021, Cuneo, Italie ; https://www.aieocuneo.unito.it/fran%C3%A7ais/organisateurs-et-partenaires (2021)
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Argumentation and Arabic Philosophy of Language
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In: https://halshs.archives-ouvertes.fr/halshs-03151284 ; CNRS-UMR -8163: STL. 22 (2), In press, Methodos. Savoirs et Textes ; https://journals.openedition.org/methodos/ (2021)
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Good Scientific Practice in MEEG Research: Progress and Perspectives
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In: https://hal.archives-ouvertes.fr/hal-03494100 ; 2021 (2021)
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Sozio-oekonomisches Panel, Daten der Jahre 1984-2019 (SOEP-Core, v36, Onsite Edition) ... : Socio-Economic Panel, data from 1984-2019, (SOEP-Core, v36, Onsite Edition) ...
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Sozio-oekonomisches Panel, Daten der Jahre 1984-2019 (SOEP-Core, v36, Remote Edition) ... : Socio-Economic Panel, data from 1984-2019, (SOEP-Core, v36, Remote Edition) ...
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Sozio-oekonomisches Panel, Daten der Jahre 1984-2019 (SOEP-Core, v36, Teaching Edition) ... : Socio-Economic Panel, data from 1984-2019, (SOEP-Core, v36, Teaching Edition) ...
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Sozio-oekonomisches Panel, Daten der Jahre 1984-2019 (SOEP-Core, v36, EU Edition) ... : Socio-Economic Panel, data from 1984-2019, (SOEP-Core, v36, EU Edition) ...
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Sozio-oekonomisches Panel, Daten der Jahre 1984-2019 (SOEP-Core, v36, International Edition) ... : Socio-Economic Panel, data from 1984-2019, (SOEP-Core, v36, International Edition) ...
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