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Syntactic and Pragmatic Factors in Children’s Comprehension of Cleft Constructions
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In: MIT Web Domain (2017)
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Shared Neuroanatomical Substrates of Impaired Phonological Working Memory Across Reading Disability and Autism
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Harris, Adrianne; Wisman Weil, Lisa; Tager-Flusberg, Helen; Lu, Chunming; Qi, Zhenghan; Han, Michelle; Halverson, Kelly; Perrachione, Tyler Kent; Kjelgaard, Margaret McCaughin; Wexler, Kenneth N; Gabrieli, John D. E.
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In: PMC (2017)
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Abstract:
Background Individuals with reading disability and individuals with autism spectrum disorder (ASD) are characterized, respectively, by their difficulties in reading and social communication, but both groups often have impaired phonological working memory (PWM). It is not known whether the impaired PWM reflects distinct or shared neuroanatomical abnormalities in these two diagnostic groups. Methods White-matter structural connectivity via diffusion weighted imaging was examined in 64 children, age 5 to 17 years, with reading disability, ASD, or typical development, who were matched on age, gender, intelligence, and diffusion data quality. Results Children with reading disability and children with ASD exhibited reduced PWM compared with children with typical development. The two diagnostic groups showed altered white matter microstructure in the temporoparietal portion of the left arcuate fasciculus and in the occipitotemporal portion of the right inferior longitudinal fasciculus (ILF), as indexed by reduced fractional anisotropy and increased radial diffusivity. Moreover, the structural integrity of the right ILF was positively correlated with PWM ability in the two diagnostic groups but not in the typically developing group. Conclusions These findings suggest that impaired PWM is transdiagnostically associated with shared neuroanatomical abnormalities in ASD and reading disability. Microstructural characteristics in left arcuate fasciculus and right ILF may play important roles in the development of PWM. The right ILF may support a compensatory mechanism for children with impaired PWM.
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URL: http://hdl.handle.net/1721.1/112144
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A Program for the Genetics of Grammar
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In: BIOLINGUISTICS; Vol. 11 (2017): Special Issue—50 Years Later: A Tribute to Eric Lenneberg’s Biological Foundations of Language; 295-324 ; 1450-3417 (2017)
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Grammar Is Differentially Impaired in Subgroups of Autism Spectrum Disorders: Evidence from an Investigation of Tense Marking and Morphosyntax
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In: Frontiers (2016)
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