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Domain-general subregions of the medial prefrontal cortex contribute to recovery of language after stroke
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Semantic memory: which side are you on?
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Abstract:
We present two patients in whom the combination of lesion site and cognitive performance was uniquely informative about the organisation and functional anatomy of semantic memory. One had had a single lobar stroke with an unusual distribution, largely destroying the whole of the left temporal lobe ventral to the superior temporal sulcus. The other patient had had herpes simplex encephalitis with destruction that was confined to the left cerebral hemisphere. The lesion again mainly encompassed the left temporal lobe, but also extended to the left inferior frontal gyrus. Cognitive outcomes in the two patients were compared with each other and with published results from patients with semantic dementia. This is because, whereas the majority of semantic dementia patients present with more prominent atrophy of the left rostroventral temporal lobe, they invariably have a degree of atrophy in the mirror region on the right that progresses. Semantic dementia therefore provides no clear evidence about the specific role of the left rostroventral temporal lobe. The two patients showed a highly consistent cognitive profile. Their deficits were also similar in many respects to that observed in patients with mild-moderate semantic dementia, including severe anomia that was not resolved by phonological cues and impairment on non-verbal as well as verbal semantic tasks. Certain key features of the semantic dementia profile, however-including sensitivity to the familiarity and typicality of the stimulus materials-appeared only in tasks requiring verbal output in these two patients with unilateral left temporal lesions. Results in these cases provide some of the first definitive evidence regarding the specific functions of the left anterior temporal lobe.
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Keyword:
2802 Behavioral Neuroscience; 2805 Cognitive Neuroscience; 3205 Experimental and Cognitive Psychology; Herpes simplex virus encephalitis; Left temporal lobe; Semantic aphasia; Semantic dementia; Stroke
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URL: https://espace.library.uq.edu.au/view/UQ:ed784b2
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Task-induced brain activity in aphasic stroke patients: what is driving recovery?
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Cognitive control and its impact on recovery from aphasic stroke
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Cognitive control and its impact on recovery from aphasic stroke
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Task-induced brain activity in aphasic stroke patients: what is driving recovery?
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The contribution of the inferior parietal cortex to spoken language production
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Hemispheric Asymmetries in Speech Perception: Sense, Nonsense and Modulations
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A comparison of sensory-motor activity during speech in first and second languages
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Two Tongues, One Brain: Imaging Bilingual Speech Production
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The Contribution of the Parietal Lobes to Speaking and Writing
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The Contribution of the Parietal Lobes to Speaking and Writing
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The contribution of the parietal lobes to speaking and writing
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The Contribution of the Parietal Lobes to Speaking and Writing
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Lexical retrieval constrained by sound structure : the role of the left inferior frontal gyrus
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Temporal lobe regions engaged during normal speech comprehension
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Language systems in normal and aphasic human subjects: functional imaging studies and inferences from animal studies
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