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The Trans-Ancestral Genomic Architecture of Glycemic Traits
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In: Nat Genet (2021)
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Accelerated epigenetic age and cognitive decline among urban-dwelling adults
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In: Neurology (2020)
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Association of Antioxidant Vitamins A, C, E and Carotenoids with Cognitive Performance over Time: A Cohort Study of Middle-Aged Adults
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In: Nutrients (2020)
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Vitamin D Status and Intakes and Their Association With Cognitive Trajectory in a Longitudinal Study of Urban Adults
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Novel genetic loci associated with hippocampal volume
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In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-01488337 ; Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩ (2017)
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
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In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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Serum uric acid and its association with longitudinal cognitive change among urban adults
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Abstract:
Uric acid, a waste metabolite among humans, was linked to various cognitive outcomes. We describe sex and age-group specific associations of baseline SUA (SUAbase) and significant change in SUA (ΔSUA: 1 vs. 0=decrease vs. no change; 2 vs. 0=Increase vs. no change) with longitudinal annual rate of cognitive change among a large sample of urban adults. Data from the Healthy Aging in Neighborhoods of Diversity across the Life Span study, 2004–2009 (visit 1) and 2009–2013 (visit 2) were used. Of 3,720 adults selected at baseline (age range:30-64y), complete data were available for N=1,487–1,602 with a mean repeat of 1.5–1.7 visits/participant. Cognitive test domains spanned attention, processing speed, learning/memory, executive function, visuo-spatial/visuo-construction ability, language/verbal and global cognitive function. SUA was measured at both visits. Multiple mixed-effect regression analyses were conducted. In the total population, a higher SUAbase was associated with a faster annual rate of decline on a measure of visual memory/visuo-construction ability (the Benton Visual Retention Test) by γ=0.07 with a standard error of 0.02, P<0.001. Among older men, a significant increase in SUA was associated with slower decline on a test of attention/processing speed, namely Trailmaking test, Part A, measured in seconds to completion (γ=−6.91±1.73, p<0.001). In sum, a higher SUAbase was associated with faster cognitive decline over-time in a visual memory/visuo-construction ability test. ΔSUA had particular beneficial effects of an increasing ΔSUA on the domain of attention/processing speed among older men. More longitudinal studies are needed to examine cognitive domain-specific effects of over-time change in SUA within sex and age groups.
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Article
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URL: http://www.ncbi.nlm.nih.gov/pubmed/27104899
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902772/
https://doi.org/10.3233/JAD-160028
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| 8 |
Common genetic variants influence human subcortical brain structures.
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In: ISSN: 0028-0836 ; EISSN: 1476-4679 ; Nature ; https://hal.archives-ouvertes.fr/hal-01196805 ; Nature, Nature Publishing Group, 2015, 520 (7546), pp.224-9. ⟨10.1038/nature14101⟩ (2015)
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