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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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Miyagawa, Toji; Brushaber, Danielle; Syrjanen, Jeremy; Kremers, Walter; Fields, Julie; Forsberg, Leah K; Heuer, Hilary W; Knopman, David; Kornak, John; Boxer, Adam; Rosen, Howie; Boeve, Bradley; ARTFL/LEFFTDS Consortium
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Abstract:
IntroductionBehavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR®) for improving evaluation of patients with frontotemporal lobar degeneration (FTLD) (CDR® plus NACC FTLD).MethodsWe analyzed the CDR® plus NACC FTLD among participants from the baseline visit of the Advancing Research and Treatment for Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Consortium.ResultsThe CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR® sum of boxes (CDR®-SB)=0. The CDR®-SB was not sensitive, particularly in participants with mild nonfluent/agrammatic primary progressive aphasia. Participants with familial and sporadic behavioral variant FTD exhibited similar CDR® plus NACC FTLD profiles except that language impairment was more frequent in participants with mild sporadic behavioral variant FTD. Adding the BEHAV and/or LANG domains to the CDR®-SB significantly enhanced discriminatory power in differentiating among the FTLD spectrum disorders.DiscussionThe BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD.
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Keyword:
Acquired Cognitive Impairment; Adult; Aged; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); ARTFL/LEFFTDS Consortium; Behavior; Behavioral and Social Science; Brain Disorders; CDR; CDR®; Clinical Research; Clinical Sciences; Comportment and personality; Cross-Sectional Studies; Dementia; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Frontotemporal Lobar Degeneration; Geriatrics; Humans; Language; Mental Status and Dementia Tests; Middle Aged; NACC FTLD Module; Neurodegenerative; Neurosciences; Personality; Primary progressive aphasia; Primary progressive aphasia Language; Rare Diseases
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URL: https://escholarship.org/uc/item/6np868k1
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Play and prosociality are associated with fewer externalizing problems in children with developmental language disorder: The role of early language and communication environment. ...
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Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.
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In: Genetics in medicine : official journal of the American College of Medical Genetics, vol 21, iss 8 (2019)
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A Mechanistic Framework for Explaining Audience Design in Language Production.
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In: Annual review of psychology, vol 70, iss 1 (2019)
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Integrating a Parent-Implemented Blend of Developmental and Behavioral Intervention Strategies into Speech-Language Treatment for Toddlers at Risk for Autism Spectrum Disorder.
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In: Seminars in speech and language, vol 39, iss 2 (2018)
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A method to develop vocabulary checklists in new languages and their validity to assess early language development.
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In: Journal of health, population, and nutrition, vol 37, iss 1 (2018)
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Mothers speak differently to infants at-risk for dyslexia. ...
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Self-help and help-seeking for communication disability in Ghana: implications for the development of communication disability rehabilitation services.
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Auditory Deprivation Does Not Impair Executive Function, But Language Deprivation Might: Evidence From a Parent-Report Measure in Deaf Native Signing Children.
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In: Journal of deaf studies and deaf education, vol 22, iss 1 (2017)
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Parental embodied mentalizing: how the nonverbal dance between parents and infants predicts children's socio-emotional functioning.
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In: Attachment & human development, vol 19, iss 2 (2017)
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A common neural hub resolves syntactic and non-syntactic conflict through cooperation with task-specific networks.
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Large-Scale Behavior-Change Initiative for Infant and Young Child Feeding Advanced Language and Motor Development in a Cluster-Randomized Program Evaluation in Bangladesh
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In: Faculty Publications (2017)
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Maternal vocal feedback to 9-month-old infant siblings of children with ASD
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Contingencies Between Infants' Gaze, Vocal, and Manual Actions and Mothers' Object-Naming: Longitudinal Changes From 4 to 9 Months.
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In: Developmental neuropsychology, vol 41, iss 5-8 (2016)
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Children's use of linguistic information when learning in a bilingual context.
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In: Journal of experimental child psychology, vol 144 (2016)
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Partly segregated cortico-subcortical pathways support phonologic and semantic verbal fluency: A lesion study.
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In: Neuroscience, vol. 329, pp. 275-283 (2016)
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