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Responding to supervisory feedback: Mediated positioning in thesis writing
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Neural Mechanisms of Subliminal Mentor-Student Relationship Stimuli Processing: An ERP Study
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In: Int J Environ Res Public Health (2022)
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Grandparent–Grandchild Communication and Attitudes Toward Older Adults: Relational Solidarity and Shared Family Identity in China
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In: International Journal of Communication; Vol 15 (2021); 19 ; 1932-8036 (2021)
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Revisiting Self-training for Few-shot Learning of Language Model ...
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Bootstrapped Unsupervised Sentence Representation Learning ...
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Production d’autoreformulations autoamorcées par des apprenants adultes du français et capacité de mémoire de travail
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Linguistic features and consumer credibility judgment of online health information
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Influence of bone anatomical morphology of mandibular molars on dental implant based on CBCT
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In: BMC Oral Health (2021)
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Elements of doctoral apprenticeship: community feedback and the acquisition of writing expertise
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Production d’autoreformulations autoamorcées par des apprenants adultes du français et capacité de mémoire de travail
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In: Canadian Journal of Applied Linguistics; Vol. 24 No. 1 (2021); 138-158 ; Revue canadienne de linguistique appliquée; Vol. 24 No. 1 (2021); 138-158 ; 1920-1818 ; 1481-868X (2021)
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Grammar choices for graduate and professional writers (2nd ed.) Nigel A. Caplan Michigan: The university of Michigan Press, 2019. 216 pages. ISBN: 978-0-472-03731-5
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In: Ibérica: Revista de la Asociación Europea de Lenguas para Fines Específicos ( AELFE ), ISSN 1139-7241, Nº. 40, 2020, pags. 279-283 (2020)
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Densely Connected Graph Convolutional Networks for Graph-to-Sequence Learning
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In: Transactions of the Association for Computational Linguistics, Vol 7, Pp 297-312 (2019) (2019)
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Operon mRNAs are organized into ORF-centric structures that predict translation efficiency
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In: eLife (2018)
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An extended Levinson-Durbin algorithm and its application in mixed excitation linear prediction
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Maritime English as a code-tailored ESP: Genre-based curriculum development as a way out
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In: Ibérica: Revista de la Asociación Europea de Lenguas para Fines Específicos ( AELFE ), ISSN 1139-7241, Nº. 35, 2018, pags. 145-170 (2018)
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Operon mRNAs are organized into ORF-centric structures that predict translation efficiency
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Abstract:
Bacterial mRNAs are organized into operons consisting of discrete open reading frames (ORFs) in a single polycistronic mRNA. Individual ORFs on the mRNA are differentially translated, with rates varying as much as 100-fold. The signals controlling differential translation are poorly understood. Our genome-wide mRNA secondary structure analysis indicated that operonic mRNAs are comprised of ORF-wide units of secondary structure that vary across ORF boundaries such that adjacent ORFs on the same mRNA molecule are structurally distinct. ORF translation rate is strongly correlated with its mRNA structure in vivo, and correlation persists, albeit in a reduced form, with its structure when translation is inhibited and with that of in vitro refolded mRNA. These data suggest that intrinsic ORF mRNA structure encodes a rough blueprint for translation efficiency. This structure is then amplified by translation, in a self-reinforcing loop, to provide the structure that ultimately specifies the translation of each ORF.
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Keyword:
Computational and Systems Biology
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URL: https://doi.org/10.7554/eLife.22037 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318159/ http://www.ncbi.nlm.nih.gov/pubmed/28139975
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Query answering with inconsistent existential rules under stable model semantics
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