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Crossed cerebellar diaschisis on 18 F-FDG PET: Frequency across neurodegenerative syndromes and association with 11 C-PIB and 18 F-Flortaucipir ...
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Crossed cerebellar diaschisis on 18 F-FDG PET: Frequency across neurodegenerative syndromes and association with 11 C-PIB and 18 F-Flortaucipir ...
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Crossed cerebellar diaschisis on (18)F-FDG PET: Frequency across neurodegenerative syndromes and association with (11)C-PIB and (18)F-Flortaucipir
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In: J Cereb Blood Flow Metab (2021)
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Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
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In: Neurology (2021)
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Connected speech markers of amyloid burden in primary progressive aphasia
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Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
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Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
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In: Am J Speech Lang Pathol (2020)
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Longitudinal structural and metabolic changes in frontotemporal dementia
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In: Neurology (2020)
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Effects of bilingualism on age of onset in two clinical Alzheimer’s disease variants
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In: Alzheimers Dement (2020)
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Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
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In: Brain communications, vol 1, iss 1 (2019)
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Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
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In: Brain communications, vol 1, iss 1 (2019)
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Alzheimer’s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation
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Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia
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Miller, Zachary A; Spina, Salvatore; Pakvasa, Mikhail; Rosenberg, Lynne; Watson, Christa; Mandelli, Maria Luisa; Paredes, Mercedes F; Joie, Renaud La; Rabinovici, Gil D; Rosen, Howard J; Grinberg, Lea T; Huang, Eric J; Miller, Bruce L; Seeley, William W; Gorno-Tempini, Maria Luisa
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In: Brain Commun (2019)
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Abstract:
An increased prevalence of dyslexia has been observed in individuals diagnosed with primary progressive aphasia, most notably the logopenic variant primary progressive aphasia. The underlying pathology most commonly associated with logopenic variant primary progressive aphasia is Alzheimer’s disease. In this clinical case report series, we describe the neuropathological findings of three patients with logopenic variant primary progressive aphasia and developmental dyslexia, each demonstrating a pattern of cerebrocortical microdysgenesis, reminiscent of findings first reported in dyslexic individuals, alongside expected Alzheimer’s disease pathology. Neurodevelopmental and most severe Alzheimer’s disease pathological changes overlapped within perisylvian brain regions, areas associated with phonological deficits in both logopenic variant primary progressive aphasia and dyslexia. These three cases with pathological findings support the hypothesis that early-life neurodevelopmental changes might influence later-life susceptibility to neurodegenerative disease and could contribute to non-amnestic, early age-of-onset presentations of Alzheimer’s disease. Larger studies investigating neurobiological vulnerability across the lifespan are needed.
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Original Article
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URL: https://doi.org/10.1093/braincomms/fcz027 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364264/ http://www.ncbi.nlm.nih.gov/pubmed/32699834
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia
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Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia
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