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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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What does the brain of children with developmental dyslexia tell us about reading improvement? ERP evidence from an intervention study
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In: Frontiers in Human Neuroscience (2014)
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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What does the brain of children with developmental dyslexia tell us about reading improvement? ERP evidence from an intervention study
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Predictors of developmental dyslexia in European orthographies with varying complexity.
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In: ISSN: 0021-9630 ; EISSN: 1469-7610 ; Journal of Child Psychology and Psychiatry ; https://hal.archives-ouvertes.fr/hal-00965034 ; Journal of Child Psychology and Psychiatry, Wiley, 2013, 54 (6), pp.686-94. ⟨10.1111/jcpp.12029⟩ (2013)
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.
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Becker, Jessica; Czamara, Darina; Scerri, Tom S; Ramus, Franck; Csépe, Valéria; Talcott, Joel B; Stein, John; Morris, Andrew; Ludwig, Kerstin U; Hoffmann, Per; Honbolygó, Ferenc; Tóth, Dénes; Fauchereau, Fabien; Bogliotti, Caroline; Iannuzzi, Stéphanie; Chaix, Yves; Valdois, Sylviane; Billard, Catherine; George, Florence; Soares-Boucaud, Isabelle; Gérard, Christophe-Loïc; Van Der Mark, Sanne; Schulz, Enrico; Vaessen, Anniek; Maurer, Urs; Lohvansuu, Kaisa; Lyytinen, Heikki; Zucchelli, Marco; Brandeis, Daniel; Blomert, Leo; Leppänen, Paavo Ht; Bruder, Jennifer; Monaco, Anthony P; Müller-Myhsok, Bertram; Kere, Juha; Landerl, Karin; Nöthen, Markus M; Schulte-Körne, Gerd; Paracchini, Silvia; Peyrard-Janvid, Myriam; Schumacher, Johannes
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In: ISSN: 1018-4813 ; EISSN: 1476-5438 ; European Journal of Human Genetics ; https://hal.archives-ouvertes.fr/hal-00964958 ; European Journal of Human Genetics, Nature Publishing Group, 2013, epub ahead of print. ⟨10.1038/ejhg.2013.199⟩ (2013)
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Abstract:
International audience ; : Dyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from understanding the molecular mechanisms leading to the disorder. Several candidate genes have been implicated in dyslexia, including DYX1C1, DCDC2, KIAA0319, and the MRPL19/C2ORF3 locus, each with reports of both positive and no replications. We generated a European cross-linguistic sample of school-age children - the NeuroDys cohort - that includes more than 900 individuals with dyslexia, sampled with homogenous inclusion criteria across eight European countries, and a comparable number of controls. Here, we describe association analysis of the dyslexia candidate genes/locus in the NeuroDys cohort. We performed both case-control and quantitative association analyses of single markers and haplotypes previously reported to be dyslexia-associated. Although we observed association signals in samples from single countries, we did not find any marker or haplotype that was significantly associated with either case-control status or quantitative measurements of word-reading or spelling in the meta-analysis of all eight countries combined. Like in other neurocognitive disorders, our findings underline the need for larger sample sizes to validate possibly weak genetic effects.European Journal of Human Genetics advance online publication, 11 September 2013; doi:10.1038/ejhg.2013.199.
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Keyword:
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
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URL: https://hal.archives-ouvertes.fr/hal-00964958 https://doi.org/10.1038/ejhg.2013.199
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The time course of reading processes in children with and without dyslexia: an ERP study
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In: Frontiers in human neuroscience (2013)
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The time course of reading processes in children with and without dyslexia: an ERP study
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Evidence for the late MMN as a neurophysiological endophenotype for dyslexia.
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In: PLOS ONE (2012)
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Evidence for the late MMN as a neurophysiological endophenotype for dyslexia. ...
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Evidence for the Late MMN as a Neurophysiological Endophenotype for Dyslexia
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The Aromatase Gene CYP19A1: Several Genetic and Functional Lines of Evidence Supporting a Role in Reading, Speech and Language
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Evidence for the Late MMN as a Neurophysiological Endophenotype for Dyslexia
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Support Systems for Poor Readers: Empirical Data From Six EU Member States
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In: ISSN: 0022-2194 ; Journal of Learning Disabilities ; https://hal.archives-ouvertes.fr/hal-01440410 ; Journal of Learning Disabilities, SAGE Publications, 2011, 44 (3), pp.228-245. ⟨10.1177/0022219410374235⟩ (2011)
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Slow perceptual processing at the core of developmental dyslexia: A parameter-based assessment of visual attention
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