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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 10 of 10 1 Evaluation and Minimization of Cas9-Independent Off-Target DNA Editing by Cytosine Base Editors Doman, Jordan L.; Raguram, Aditya; Newby, Gregory A.; Liu, David R. In: Nat Biotechnol (2020) Abstract: Cytosine base editors (CBEs) enable targeted C•G-to-T•A conversions in genomic DNA. Recent studies report that BE3, the original CBE, induces a low frequency of genome-wide Cas9-independent off-target C•G-to-T•A deamination in mouse embryos and in rice. Here we develop multiple rapid, cost-effective methods to screen the propensity of different CBEs to induce Cas9-independent deamination in E. coli and in human cells. We use these assays to identify CBEs with reduced Cas9-independent deamination and validate via whole-genome sequencing that YE1, a narrowed-window CBE variant, displays background levels of Cas9-independent off-target editing. We engineered YE1 variants that retain the substrate-targeting scope of high-activity CBEs while maintaining minimal Cas9-independent off-target editing. The suite of CBEs characterized and engineered in this study collectively offer ~10- to 100-fold lower average Cas9-independent off-target DNA editing while maintaining robust on-target editing at most positions targetable by canonical CBEs, and thus are especially promising for applications in which off-target editing must be minimized. Keyword: Article URL: http://www.ncbi.nlm.nih.gov/pubmed/32042165 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335424/ https://doi.org/10.1038/s41587-020-0414-6 BASE Hide details 2 Neural correlates of children's theory of mind development Liu, David; Sabbagh, Mark A.; Gehring, William J.... In: Child development. - Malden, Ma. [u.a.] : Blackwell 80 (2009) 2, 318-326 BLLDB Show details 3 Neural correlates of belief- and desire-reasoning Liu, David; Meltzoff, Andrew; Wellman, Henry M. In: Child development. - Malden, Ma. [u.a.] : Blackwell 80 (2009) 4, 1163-1171 BLLDB Show details 4 Theory of mind development in Chinese children: a meta-analysis of false-belief understanding across cultures and languages Liu, David; Wellman, Henry M.; Tardif, Twila... In: Developmental psychology. - Richmond, Va. [u.a.] : American Psychological Association 44 (2008) 2, 523-531 BLLDB Show details 5 Preschoolers' understanding of knowing-that and knowing-how in the United States and Hong Kong Tardif, Twila; Wellman, Henry M.; Fong Fung, Kitty Yau... In: Developmental psychology. - Richmond, Va. [u.a.] : American Psychological Association 41 (2005) 3, 562-573 BLLDB Show details 6 Preschoolers' understanding of knowing-that and knowing-how in the United States and Hong Kong Tardif, Twila; Wellman, Henry M.; Fong Fung, Kitty Yau... In: Developmental psychology. - Richmond, Va. [u.a.] : American Psychological Association 41 (2005) 3, 562-573 BLLDB Show details 7 Steps in theory-of-mind development for children with deafness or autism Peterson, Candida C.; Wellman, Henry M.; Liu, David In: Child development. - Malden, Ma. [u.a.] : Blackwell 76 (2005) 2, 502-517 BLLDB Show details 8 Scaling of theory-of-mind tasks Wellman, Henry M.; Liu, David In: Child development. - Malden, Ma. [u.a.] : Blackwell 75 (2004) 2, 523-541 BLLDB Show details 9 Automated Suggestions for Miscollocations Anne Li-e; Liu David; Wible Nai-lung Tsao In: http://www.cs.rochester.edu/u/tetreaul/bea4/Liu-BEA4.pdf BASE Show details 10 Automated Suggestions for Miscollocations Anne Li-e; Liu David; Wible Nai-lung Tsao In: http://aclweb.org/anthology-new/W/W09/W09-2107.pdf BASE Show details

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