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Data from: ApoE is a correlate of phenotypic heterogeneity in Alzheimer’s disease in a national cohort ...
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2
The functional role of the Carabelli trait in early and late hominins
Fiorenza, L.; Menter, C.G.; Fung, S.. - : Elsevier, 2020
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3
APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort
In: Neurology (2020)
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4
Fear, Affective Semiosis, and Management of the Pandemic Crisis: Covid-19 as Semiotic Vaccine?
In: Clin Neuropsychiatry (2020)
BASE
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5
Withdrawal from cocaine self-administration alters the regulation of protein translation in the nucleus accumbens
Abstract: BACKGROUND: Cue-induced cocaine craving “incubates” during abstinence from cocaine self-administration. Expression of incubation ultimately depends upon elevation of homomeric GluA1 AMPA receptors (AMPARs) in the nucleus accumbens (NAc). This adaptation requires ongoing protein translation for its maintenance. Aberrant translation is implicated in CNS diseases, but nothing is known about glutamatergic regulation of translation in the drug-naïve NAc or after incubation. METHODS: NAc tissue was obtained from drug-naïve rats and after 1 or >40 days of abstinence from extended-access cocaine or saline self-administration. Newly translated proteins were labeled using (35)S-Met/Cys or puromycin. We compared basal overall translation and its regulation by mGlu1, mGlu5 and NMDA receptors (NMDARs) in naïve, saline and cocaine rats, and compared GluA1 and GluA2 translation by immunoprecipitating puromycin-labeled proteins. RESULTS: In all groups, overall translation was unaltered by mGlu1 blockade (LY367385) but increased by mGlu5 blockade (MTEP). NMDAR blockade (APV) increased overall translation in naïve and saline, but not cocaine, rats. Cocaine/late withdrawal rats exhibited greater translation of GluA1 (but not GluA2), which was not further affected by NMDAR blockade. CONCLUSIONS: Our results suggest that increased GluA1 translation contributes to the elevated homomeric GluA1 AMPAR levels in NAc that mediate incubation. Additional contributions to incubation-related plasticity may result from loss of the braking influence on translation normally exerted by NMDARs. Apart from elucidating incubation-related adaptations, we found a suppressive effect of mGlu5 on NAc translation regardless of drug exposure, which is opposite to results obtained in hippocampus and points to heterogeneity of translational regulation between brain regions.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pubmed/29622268
https://doi.org/10.1016/j.biopsych.2018.02.012
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054574/
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6
NALBB: Enquête dialectologique à Scaër - Questionnaire (2)
Le Dû, Jean; Miossec, Yves; C.G.. - : Centre de Recherche Bretonne et Celtique, 2013
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7
NALBB: Enquête dialectologique à Scaër - Questionnaire (1)
Le Dû, Jean; Miossec, Yves; C.G.. - : Centre de Recherche Bretonne et Celtique, 2013
BASE
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8
18F-FDG PET imaging analysis for computer aided Alzheimer’s diagnosis
In: Information sciences. - New York, NY : Elsevier Science Inc. 181 (2011) 4, 903-916
OLC Linguistik
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9
NALBB: Enquête dialectologique à Camlez (2)
Le Dû, Jean; C.G.. - : Centre de Recherche Bretonne et Celtique, 2011
BASE
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10
NALBB: Enquête dialectologique à Camlez (1)
Le Dû, Jean; C.G.. - : Centre de Recherche Bretonne et Celtique, 2011
BASE
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11
Effectiveness of Lexico-Syntactic Pattern Matching for Ontology Enrichment with Clinical Documents
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12
Visual properties of neurons in inferotemporal cortex of the macaque
In: Cognitive neuroscience (New York, 2009), 2 ; 104-124
MPI für Psycholinguistik
13
fMRI Activity Correlated With Auditory Hallucinations During Performance of a Working Memory Task: Data From the FBIRN Consortium Study
Wible, C.G.; Lee, K.; Molina, I.. - : Oxford University Press, 2009
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14
fMRI Activity Correlated With Auditory Hallucinations During Performance of a Working Memory Task: Data From the FBIRN Consortium Study
Wible, C.G.; Lee, K.; Molina, I.. - : Oxford University Press, 2009
BASE
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15
Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.
In: Archives of internal medicine, vol. 169, no. 5, pp. 463-473 (2009)
BASE
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16
Postmodernism for Historians
Brown, C.G.. - : Pearson/Longman, 2005
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17
How does science express uncertainty ?
In: Language, thought and reality (Colombia, CS, 2004), p. 355-366
MPI für Psycholinguistik
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18
Why distinctive information reduces false memories : evidence for both impoverished relational-encoding and distinctiveness heuristic accounts
In: Journal of experimental psychology. Learning, memory, and cognition. - Washington, DC [u.a.] : Assoc. 30 (2004) 4, 787-795
BLLDB
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19
Canetti and the Question of Genre
Preece, Julian E.. - : Boydell & Brewer Ltd; Camden House Inc. (imprint), 2004
BASE
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20
The holy Qur'ans : a corpus comparison of three English versions
In: Linguistics and the real world (Columbia, SC, 2003), p. 91-98
MPI für Psycholinguistik
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