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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 4 5...8 Hits 1 – 20 of 157 1 Cortical microstructure in primary progressive aphasia: a multicenter study. Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi; Mandelli, Maria Luisa; Falgàs, Neus; Welch, Ariane E; Pegueroles, Jordi; Santos-Santos, Miguel; Bejanin, Alexandre; Alcolea, Daniel; Dols-Icardo, Oriol; Belbin, Olivia; Sánchez-Saudinós, Mª Belén; Bargalló, Nuria; González-Ortiz, Sofía; Lladó, Albert; Blesa, Rafael; Dickerson, Bradford C; Rosen, Howard J; Miller, Bruce L; Lleó, Alberto; Gorno-Tempini, Maria Luisa; Sánchez-Valle, Raquel; Fortea, Juan In: Alzheimer's research & therapy, vol 14, iss 1 (2022) Abstract: BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).MethodsIn this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.ResultsThe comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.ConclusionsCortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA. Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Biomedical Imaging; Brain Disorders; Case-Control Studies; Clinical Research; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Frontotemporal Dementia (FTD); Frontotemporal lobar degeneration; Humans; Magnetic resonance; Magnetic Resonance Imaging; Medical and Health Sciences; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Primary progressive aphasia; Rare Diseases URL: https://escholarship.org/uc/item/4td346vg BASE Hide details 2 Neuroanatomical correlations of visuospatial processing in primary progressive aphasia Tee, Boon Lead; Watson Pereira, Christa; Lukic, Sladjana... In: Brain Commun (2022) BASE Show details 3 Editorial: The Unusual Suspects: Linguistic Deficits in Non-Language-Dominant Neurodegenerative Diseases García, Adolfo M.; Ibáñez, Agustín; Miller, Bruce... In: Front Aging Neurosci (2022) BASE Show details 4 Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant Saracino, Dario; Ferrieux, Sophie; NOGUES-LASSIAILLE, Marie... In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021) BASE Show details 5 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021) BASE Show details 6 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021) BASE Show details 7 Speech Metrics and Samples That Differentiate Between Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia Haley, Katarina L.; Jacks, Adam; Jarrett, Jordan... In: J Speech Lang Hear Res (2021) BASE Show details 8 Treatment for Anomia in Bilingual Speakers with Progressive Aphasia Grasso, Stephanie M.; Peña, Elizabeth D.; Kazemi, Nina... In: Brain Sci (2021) BASE Show details 9 Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia Dial, Heather R.; Gnanateja, G. Nike; Tessmer, Rachel S.... In: Front Hum Neurosci (2021) BASE Show details 10 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring Staffaroni, Adam M.; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimers Dement (Amst) (2021) BASE Show details 11 Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET La Joie, Renaud; Visani, Adrienne V.; Lesman-Segev, Orit H.... In: Neurology (2021) BASE Show details 12 Connected speech markers of amyloid burden in primary progressive aphasia Slegers, Antoine; Chafouleas, Geneviève; Montembeault, Maxime. - : Elsevier, 2021 BASE Show details 13 Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example Europa, Eduardo; Iaccarino, Leonardo; Perry, David C. - : eScholarship, University of California, 2020 BASE Show details 14 Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease. Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020 BASE Show details 15 Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease. Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020 BASE Show details 16 Data-Driven, Visual Framework for the Characterization of Aphasias Across Stroke, Post-resective, and Neurodegenerative Disorders Over Time. Fan, Joline M; Gorno-Tempini, Maria Luisa; Dronkers, Nina F. - : eScholarship, University of California, 2020 BASE Show details 17 Speech and language therapy approaches to managing primary progressive aphasia Volkmer, Anna; Rogalski, Emily; Henry, Maya. - : BMJ Publishing Group Ltd, 2020 BASE Show details 18 PPA diagnosis (Europa et al., 2020) ... Europa, Eduardo; Iaccarino, Leonardo; Perry, David C.. - : ASHA journals, 2020 BASE Show details 19 PPA diagnosis (Europa et al., 2020) ... Europa, Eduardo; Iaccarino, Leonardo; Perry, David C.. - : ASHA journals, 2020 BASE Show details 20 Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates ... Vinceti, Giulia; Olney, Nicholas; Mandelli, Maria Luisa. - : Taylor & Francis, 2020 BASE Show details Page: 1 2 3 4 5...8

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