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1
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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2
Neuroanatomical correlations of visuospatial processing in primary progressive aphasia
In: Brain Commun (2022)
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3
Editorial: The Unusual Suspects: Linguistic Deficits in Non-Language-Dominant Neurodegenerative Diseases
In: Front Aging Neurosci (2022)
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4
Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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5
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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6
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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7
Speech Metrics and Samples That Differentiate Between Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia
In: J Speech Lang Hear Res (2021)
Abstract: PURPOSE: Of the three currently recognized variants of primary progressive aphasia, behavioral differentiation between the nonfluent/agrammatic (nfvPPA) and logopenic (lvPPA) variants is particularly difficult. The challenge includes uncertainty regarding diagnosis of apraxia of speech, which is subsumed within criteria for variant classification. The purpose of this study was to determine the extent to which a variety of speech articulation and prosody metrics for apraxia of speech differentiate between nfvPPA and lvPPA across diverse speech samples. METHOD: The study involved 25 participants with progressive aphasia (10 with nfvPPA, 10 with lvPPA, and five with the semantic variant). Speech samples included a word repetition task, a picture description task, and a story narrative task. We completed acoustic analyses of temporal prosody and quantitative perceptual analyses based on narrow phonetic transcription and then evaluated the degree of differentiation between nfvPPA and lvPPA participants (with the semantic variant serving as a reference point for minimal speech production impairment). RESULTS: Most, but not all, articulatory and prosodic metrics differentiated statistically between the nfvPPA and lvPPA groups. Measures of distortion frequency, syllable duration, syllable scanning, and—to a limited extent—syllable stress and phonemic accuracy showed greater impairment in the nfvPPA group. Contrary to expectations, classification was most accurate in connected speech samples. A customized connected speech metric—the narrative syllable duration—yielded excellent to perfect classification accuracy. DISCUSSION: Measures of average syllable duration in multisyllabic utterances are useful diagnostic tools for differentiating between nfvPPA and lvPPA, particularly when based on connected speech samples. As such, they are suitable candidates for automatization, large-scale study, and application to clinical practice. The observation that both speech rate and distortion frequency differentiated more effectively in connected speech than on a motor speech examination suggests that it will be important to evaluate interactions between speech and discourse production in future research.
Keyword: Speech
URL: https://doi.org/10.1044/2020_JSLHR-20-00445
http://www.ncbi.nlm.nih.gov/pubmed/33630653
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608203/
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8
Treatment for Anomia in Bilingual Speakers with Progressive Aphasia
In: Brain Sci (2021)
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9
Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia
In: Front Hum Neurosci (2021)
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10
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
In: Alzheimers Dement (Amst) (2021)
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11
Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
In: Neurology (2021)
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12
Connected speech markers of amyloid burden in primary progressive aphasia
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13
Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
Europa, Eduardo; Iaccarino, Leonardo; Perry, David C. - : eScholarship, University of California, 2020
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14
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020
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15
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020
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16
Data-Driven, Visual Framework for the Characterization of Aphasias Across Stroke, Post-resective, and Neurodegenerative Disorders Over Time.
Fan, Joline M; Gorno-Tempini, Maria Luisa; Dronkers, Nina F. - : eScholarship, University of California, 2020
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17
Speech and language therapy approaches to managing primary progressive aphasia
Volkmer, Anna; Rogalski, Emily; Henry, Maya. - : BMJ Publishing Group Ltd, 2020
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18
PPA diagnosis (Europa et al., 2020) ...
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19
PPA diagnosis (Europa et al., 2020) ...
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20
Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates ...
Vinceti, Giulia; Olney, Nicholas; Mandelli, Maria Luisa. - : Taylor & Francis, 2020
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