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1
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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2
Neuroanatomical correlations of visuospatial processing in primary progressive aphasia
In: Brain Commun (2022)
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3
Editorial: The Unusual Suspects: Linguistic Deficits in Non-Language-Dominant Neurodegenerative Diseases
In: Front Aging Neurosci (2022)
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4
Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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5
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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6
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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7
Speech Metrics and Samples That Differentiate Between Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia
In: J Speech Lang Hear Res (2021)
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8
Treatment for Anomia in Bilingual Speakers with Progressive Aphasia
In: Brain Sci (2021)
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9
Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia
In: Front Hum Neurosci (2021)
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10
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
In: Alzheimers Dement (Amst) (2021)
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11
Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
In: Neurology (2021)
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12
Connected speech markers of amyloid burden in primary progressive aphasia
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13
Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
Europa, Eduardo; Iaccarino, Leonardo; Perry, David C. - : eScholarship, University of California, 2020
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14
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
Abstract: BackgroundIncreasing evidence shows that the semantic variant of primary progressive aphasia (svPPA) is characterized by hippocampal atrophy. However, less is known about disease-related morphological hippocampal changes. The goal of the present study is to conduct a detailed characterization of the impact of svPPA on global hippocampus volume and morphology compared with control subjects and patients with Alzheimer's disease (AD).MethodsWe measured hippocampal volume and deformation-based shape differences in 22 patients with svPPA compared with 99 patients with AD and 92 controls. Multiple Automatically Generated Templates Brain Segmentation Algorithm (MAGeT-Brain) was used on MRI images obtained at the diagnostic visit.ResultsComparable left and right hippocampal atrophy were observed in svPPA and AD. Deformation-based shape analysis showed a common pattern of morphological deformation in svPPA and AD compared with controls. More specifically, both svPPA and AD showed inward deformations in the dorsal surface of the hippocampus, from head to tail on the left side, and more limited to the anterior portion of the body in the right hemisphere. These results also pointed out that both diseases are characterized by a lateral displacement of the central part (body) of the hippocampus.DiscussionOur study provides critical new evidence of hippocampal morphological changes in svPPA, similar to those found in AD. These findings highlight the importance of considering morphological hippocampal changes as part of the anatomical profile of patients with svPPA.
Keyword: Alzheimer's disease; Alzheimer’s disease; Automated segmentation; Deformation-based shape analysis; Hippocampus; MAGeT brain; Neurosciences; Semantic variant of primary progressive aphasia
URL: https://escholarship.org/uc/item/9c4370k3
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15
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020
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16
Data-Driven, Visual Framework for the Characterization of Aphasias Across Stroke, Post-resective, and Neurodegenerative Disorders Over Time.
Fan, Joline M; Gorno-Tempini, Maria Luisa; Dronkers, Nina F. - : eScholarship, University of California, 2020
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17
Speech and language therapy approaches to managing primary progressive aphasia
Volkmer, Anna; Rogalski, Emily; Henry, Maya. - : BMJ Publishing Group Ltd, 2020
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18
PPA diagnosis (Europa et al., 2020) ...
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19
PPA diagnosis (Europa et al., 2020) ...
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20
Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates ...
Vinceti, Giulia; Olney, Nicholas; Mandelli, Maria Luisa. - : Taylor & Francis, 2020
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