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Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia.
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Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia
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Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia
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CMIP and ATP2C2 Modulate Phonological Short-Term Memory in Language Impairment
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Paper 44. Prosody and Melody in Vowel Disorder, Journal of Linguistics, 1999, 35, 489-525
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CMIP and ATP2C2 Modulate Phonological Short-Term Memory in Language Impairment
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CMIP and ATP2C2 modulate phonological short-term memory in language impairment
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Genetic and phenotypic effects of phonological short-term memory and grammatical morphology in specific language impairment
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Receptive language disorder in childhood: Familial aspects and long term outcomes: Results from a Scottish study
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Severe receptive language disorder in childhood--familial aspects and long-term outcomes: results from a Scottish study
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Receptive language disorder in childhood: Familial aspects and long term outcomes: Results from a Scottish study
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Changes in linguapalatal contact patterns during therapy for velar fronting in a 10-year-old with Down's syndrome.
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Highly Significant Linkage to the SLI1 Locus in an Expanded Sample of Individuals Affected by Specific Language Impairment
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Abstract:
Specific language impairment (SLI) is defined as an unexplained failure to acquire normal language skills despite adequate intelligence and opportunity. We have reported elsewhere a full-genome scan in 98 nuclear families affected by this disorder, with the use of three quantitative traits of language ability (the expressive and receptive tests of the Clinical Evaluation of Language Fundamentals and a test of nonsense word repetition). This screen implicated two quantitative trait loci, one on chromosome 16q (SLI1) and a second on chromosome 19q (SLI2). However, a second independent genome screen performed by another group, with the use of parametric linkage analyses in extended pedigrees, found little evidence for the involvement of either of these regions in SLI. To investigate these loci further, we have collected a second sample, consisting of 86 families (367 individuals, 174 independent sib pairs), all with probands whose language skills are 1.5 SD below the mean for their age. Haseman-Elston linkage analysis resulted in a maximum LOD score (MLS) of 2.84 on chromosome 16 and an MLS of 2.31 on chromosome 19, both of which represent significant linkage at the 2% level. Amalgamation of the wave 2 sample with the cohort used for the genome screen generated a total of 184 families (840 individuals, 393 independent sib pairs). Analysis of linkage within this pooled group strengthened the evidence for linkage at SLI1 and yielded a highly significant LOD score (MLS = 7.46, interval empirical P<.0004). Furthermore, linkage at the same locus was also demonstrated to three reading-related measures (basic reading [MLS = 1.49], spelling [MLS = 2.67], and reading comprehension [MLS = 1.99] subtests of the Wechsler Objectives Reading Dimensions). ; casl ; 74 ; pub ; 1892 ; pub ; 6
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URL: https://hdl.handle.net/20.500.12289/1892 https://doi.org/10.1086/421529 https://eresearch.qmu.ac.uk/handle/20.500.12289/1892
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Development of cue weighting in children's speech perception
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Flexibility of acoustic cue weighting in children's speech perception
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