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81
A genomewide scan identifies two novel loci involved in specific language impairment.
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; ORA review team (2002)
Abstract: Approximately 4% of English-speaking children are affected by specific language impairment (SLI), a disorder in the development of language skills despite adequate opportunity and normal intelligence. Several studies have indicated the importance of genetic factors in SLI; a positive family history confers an increased risk of development, and concordance in monozygotic twins consistently exceeds that in dizygotic twins. However, like many behavioral traits, SLI is assumed to be genetically complex, with several loci contributing to the overall risk. We have compiled 98 families drawn from epidemiological and clinical populations, all with probands whose standard language scores fall > or =1.5 SD below the mean for their age. Systematic genomewide quantitative-trait-locus analysis of three language-related measures (i.e., the Clinical Evaluation of Language Fundamentals-Revised [CELF-R] receptive and expressive scales and the nonword repetition [NWR] test) yielded two regions, one on chromosome 16 and one on 19, that both had maximum LOD scores of 3.55. Simulations suggest that, of these two multipoint results, the NWR linkage to chromosome 16q is the most significant, with empirical P values reaching 10(-5), under both Haseman-Elston (HE) analysis (LOD score 3.55; P=.00003) and variance-components (VC) analysis (LOD score 2.57; P=.00008). Single-point analyses provided further support for involvement of this locus, with three markers, under the peak of linkage, yielding LOD scores >1.9. The 19q locus was linked to the CELF-R expressive-language score and exceeds the threshold for suggestive linkage under all types of analysis performed-multipoint HE analysis (LOD score 3.55; empirical P=.00004) and VC (LOD score 2.84; empirical P=.00027) and single-point HE analysis (LOD score 2.49) and VC (LOD score 2.22). Furthermore, both the clinical and epidemiological samples showed independent evidence of linkage on both chromosome 16q and chromosome 19q, indicating that these may represent universally important loci in SLI and, thus, general risk factors for language impairment.
Keyword: Adolescent; Child; Chromosome Mapping; Chromosomes; Cohort Studies; Computer Simulation; Diseases in Twins; England; Female; Genetic; Genetic Predisposition to Disease; Genome; Genotype; Heritable; Human; Humans; Intelligence; Language Development Disorders; Language Tests; Lod Score; Male; Models; Nuclear Family; Pair 16; Pair 19; Phenotype; Preschool; Quantitative Trait; SLI Consortium; Twins; X Chromosome
URL: https://doi.org/10.1086/338649
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82
The role of genes in the etiology of specific language impairment.
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2002)
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83
Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia.
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2002)
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84
A Study of the Genetic and Environmental Etiology of Stuttering in a Selected Twin Sample
Felsenfeld, S; Kirk, K M; Zhu, G. - : Springer New York LLC, 2000
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85
Genetic and environmental origins of verbal and performance components of cognitive delay in 2-year-olds.
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; ORA review team (1999)
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86
A ballad of the Civil War [book review]
In: Farnsworth Juvenile Literature Library, Harold B. Lee Library, Brigham Young University ; Harold B. Lee Library, Brigham Young University (1998)
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87
Twelfth night, or, What you will : with new dramatic criticism and an updated bibliography
Shakespeare, William; Baker, Herschel. - New York, N.Y. : Penguin Putnam, 1998
MPI für Psycholinguistik
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88
"Twin language": a risk factor for language impairment?
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) (1998)
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89
The relationship between multiple birth children's early phonological skills and later literacy
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90
The Relationship Between Multiple Birth Children's Early Phonological Skills and Later Literacy
McMahon, Sandra; Stassi, Kelly; Dodd, Barbara. - : American Speech-Language-Hearing Association, 1998
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91
Differential genetic etiology of reading disability as a function of mathematics performance
Casto, S. D.; Pennington, B. F.; Light, Jacquelyn G.. - : Kluwer Academic Publishers; Springer Science+Business Media, 1996
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92
A Comparison of the Vocabulary Needs of Speaking and Nonspeaking Twins
In: Dissertations and Theses (1991)
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93
The application of nonlinear phonological theory to intervention with phonologically delayed twins
Bremen, Maria Verena von. - : University of British Columbia, 1990
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94
A study of language development in a set of bilingual, biracial, identical twins ; Language development in a set of bilingual, biracial identical twins.
In: Virtual Press (1985)
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95
High School and Beyond, 1980: A Longitudinal Survey of Students in the United States ... : Archival Version ...
United States Department Of Education. Institute Of Education Sciences. National Center For Education Statistics. - : ICPSR - Interuniversity Consortium for Political and Social Research, 1984
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96
High School and Beyond, 1980: A Longitudinal Survey of Students in the United States ... : Version 2 ...
United States Department Of Education. Institute Of Education Sciences. National Center For Education Statistics. - : ICPSR - Interuniversity Consortium for Political and Social Research, 1984
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97
Language performance of identical twins of preschool age
Stelck, Brian Francis.. - : University of Alberta. Department of Elementary Education., 1978
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98
Genetic and Environmental Overlap Between Chinese and English Reading-Related Skills in Chinese Children
In: http://psycnet.apa.org/psycarticles/2014-38569-001.pdf%26productCode=pa
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99
Hearing versus Seeing Identical Twins
In: http://www.comp.nus.edu.sg/~leowwk/papers/caip2013-twin.pdf
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100
Genetic influence on literacy constructs in kindergarten and first grade: evidence from a diverse twin sample.
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