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Fine-Scale Human Population Structure in Southern Africa Reflects Ecogeographic Boundaries.
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In: Genetics, vol 204, iss 1 (2016)
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A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome ...
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Torgerson, Dara G.; Levin, Albert M.; Wilson, James G.; Hartert, Tina; Olopade, Christopher; Johnston, Henry Richard; Kumar, Rajesh; Ware, Lorraine B.; Herrera-Paz, Edwin Francisco; Avila, Pedro C.; Faruque, Mezbah U.; Huang, Lili; Ober, Carole; Marrugo, Javier; Olopade, Olufunmilayo; Gignoux, Christopher R.; Kenny, Eimear E.; Vergara, Candelaria; Eng, Celeste; Caraballo, Luis; Araujo, Maria Ilma; Ruczinski, Ingo; Bamshad, Michael; Taub, Margaret A.; Torres, Raul; Mayorga, Alvaro; Mejia-Mejia, Delmy-Aracely; Watson, Harold; Padhukasahasram, Badri; Williams, L. Keoki; Scott, Alan F.; Song, Wei; Meyers, Deborah; Pino-Yanes, Maria; Ortega, Victor E.; Fu, Wenqing; Boorgula, Meher Preethi; Mathias, Rasika Ann; Bleecker, Eugene; Nicolae, Dan L.; O'Connor, Timothy D.; Dunston, Georgia M.; Musharoff, Shaila; Beaty, Terri H.; Shringarpure, Suyash S.; Ford, Jean G.; Burchard, Esteban G.; Lange, Leslie A.; Hernandez, Ryan D.; Ferguson, Trevor. - : The University of North Carolina at Chapel Hill University Libraries, 2016
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Abstract:
The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene ...
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URL: https://cdr.lib.unc.edu/concern/articles/p5547x393 https://dx.doi.org/10.17615/svad-an83
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A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
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BASE
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Show details
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Fine-Scale Human Population Structure in Southern Africa Reflects Ecogeographic Boundaries
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BASE
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Show details
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History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico
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