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1
The Autism Phenome Project: Toward Identifying Clinically Meaningful Subgroups of Autism
In: Front Neurosci (2022)
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2
A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder
Abstract: Objective: Selective serotonin reuptake inhibitors like sertraline have been shown in observational studies and anecdotal reports to improve language development in young children with fragile X syndrome (FXS). A previous controlled trial of sertraline in young children with FXS found significant improvement in expressive language development as measured by the Mullen Scales of Early Learning (MSEL) among those with comorbid autism spectrum disorder (ASD) in post hoc analysis, prompting the authors to probe whether sertraline is also indicated in nonsyndromic ASD. Methods: The authors evaluated the efficacy of 6 months of treatment with low-dose sertraline in a randomized, double-blind, placebo-controlled trial in 58 children with ASD aged 24 to 72 months. Results: 179 subjects were screened for eligibility, and 58 were randomized to sertraline (32) or placebo (26). Eight subjects from the sertraline arm and five from the placebo arm discontinued. Intent-to-treat analysis showed no significant difference from placebo on the primary outcomes (MSEL expressive language raw score and age equivalent combined score) or secondary outcomes. Sertraline was well tolerated, with no difference in side effects between sertraline and placebo groups. No serious adverse events possibly related to study treatment occurred. Conclusion: This randomized controlled trial of sertraline treatment showed no benefit with respect to primary or secondary outcome measures. For the 6-month period, treatment in young children with ASD appears safe, although the long-term side effects of low-dose sertraline in early childhood are unknown. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT02385799.
Keyword: Psychiatry
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851992/
https://doi.org/10.3389/fpsyt.2019.00810
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3
Metformin treatment in young children with fragile X syndrome
Biag, Hazel Maridith B.; Potter, Laura A.; Wilkins, Victoria. - : John Wiley and Sons Inc., 2019
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4
The Multilingual CID-5: A New Tool to Study the Perception of Communicative Interactions in Different Languages
Manera, Valeria; Ianì, Francesco; Bourgeois, Jérémy. - : Frontiers Media S.A., 2015
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5
The multilingual CID-5: A new tool to study the perception of communicative interactions in different languages
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6
Sertraline May Improve Language Developmental Trajectory in Young Children with Fragile X Syndrome: A Retrospective Chart Review
Indah Winarni, Tri; Chonchaiya, Weerasak; Adams, Evan. - : Hindawi Publishing Corporation, 2012
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7
Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments
In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 75 (2011) 3, 255-260
OLC Linguistik
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8
Holistic crowding of Mooney faces
BASE
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9
Can young infants add and subtract? : (incl. reply and author's reply)
In: Child development. - Malden, Ma. [u.a.] : Blackwell 71 (2000) 6, 1525-1539
BLLDB
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10
The drawbridge phenomenon : representational reasoning or perceptual preference?
In: Developmental psychology. - Richmond, Va. [u.a.] : American Psychological Association 35 (1999) 2, 427-435
BLLDB
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11
Effects of alcohol on speech : durations of isolated words, sentences and passages
In: Progress report no. 17 (1991) (Bloomington, IN, 1991), P. 285-302
MPI für Psycholinguistik
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12
Measuring the workload of comprehending spoken discourse : a first report
In: Progress report no. 16 (Bloomington, IN, 1990), P. 155-168
MPI für Psycholinguistik
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13
Effects of text structure on the comprehension of natural and synthetic speech
In: Progress report no. 16 (Bloomington, IN, 1990), P. 215-232
MPI für Psycholinguistik
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