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Hybrid models of cognition: The influence of modal and amodal cues in language processing tasks
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Perspectives on dog–human interactions ; Perspektiven von Mensch-Hund-Interaktionen
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The role of occipital temporal cortex in the formation of face familiarity and identity
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Wild jackdaws respond to their partner's distress, but not with consolation
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Nichtbewußtsein : über die affektiv-digitale Transformation eines humanen Kernbereichs : ein erster Entwurf
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In: <Titel nicht gefunden> (2020)
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UB Frankfurt Linguistik
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Human face recognition in horses: data in favor of a holistic process
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In: ISSN: 1664-1078 ; Frontiers in Psychology ; https://hal.inrae.fr/hal-03151453 ; Frontiers in Psychology, Frontiers, 2020, 11, pp.1-7. ⟨10.3389/fpsyg.2020.575808⟩ (2020)
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The importance of fast auditory processing for central learning mechanisms and related feedback adaptation processes to the auditory periphery ...
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Neurocognitive functioning and health-related quality of life in adult medulloblastoma patients: long-term outcomes of the NOA-07 study
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Dirven, Linda; Luerding, Ralph; Beier, Dagmar; Bumes, Elisabeth; Reinert, Christiane; Seidel, Clemens; Bonsanto, Matteo Mario; Bremer, Michael; Rieken, Stefan; Combs, Stephanie E.; Herrlinger, Ulrich; Seliger, Corinna; Kuntze, Holger; Mayer-Steinacker, Regine; Dieing, Annette; Bartels, Claudius; Schnell, Oliver; Weyerbrock, Astrid; Seidel, Sabine; Grauer, Oliver; Nadji-Ohl, Minou; Paulsen, Frank; Weller, Michael; Wick, Wolfgang; Hau, Peter
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In: Journal of neuro-oncology. - 148, 1 (2020) , 117-130, ISSN: 1573-7373 (2020)
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Abstract:
Background Combined radiochemotherapy followed by maintenance chemotherapy with cisplatin, lomustine and vincristine within the NOA-07 study resulted in considerable short-term toxicity in adult medulloblastoma patients. Here we investigated the long-term impact of this treatment, focusing on neurocognitive functioning and health-related quality of life (HRQoL). Methods Neurocognitive functioning and HRQoL scores over time were determined, and differences between the post-treatment and follow-up assessments were calculated up to 18 months for neurocognition and 60 months for HRQoL. Results 28/30 patients were analyzed. The three preselected HRQoL scales (role, social and cognitive functioning) showed improved scores, to a clinically relevant extent (≥ 10 points), compared to post-treatment levels up to 30 months, but decreased afterwards. Z-scores for verbal working memory were worse during follow-up compared to post-treatment scores and remained impaired during 18 months follow-up (i.e. z-score below − 1 standard deviation). Attention was impaired post-treatment, and remained impaired to a clinically relevant extent during follow-up. Coordination/processing speed and lexical verbal fluency improved compared to post-treatment scores, and remained within the normal range thereafter. Other tests of verbal fluency were stable over time, with z-scores within the normal range. Conclusions This long-term follow-up study showed that the NOA-07 treatment regimen was not associated with a deterioration in HRQoL in the post-treatment period. Verbal working memory deteriorated, while other neurocognitive domains did not seem to be impacted negatively by the treatment.
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Keyword:
Hirntumor; Kognition; Lebensqualität; Neuroblastom; Toxizität
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URL: https://doi.org/10.1007/s11060-020-03502-y
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-1665173
https://www.freidok.uni-freiburg.de/dnb/download/166517
https://freidok.uni-freiburg.de/data/166517
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The importance of fast auditory processing for central learning mechanisms and related feedback adaptation processes to the auditory periphery
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Theoretical and corpus-based investigation of the relation between sensorimotor processes and linguistic structure
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Vermin, parasites, puppeteers - the contribution of antisemitic metaphors to social categorization
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Different or the Same? Determination of Discriminatory Power Threshold and Category Formation for Vague Linguistic Frequency Expressions
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Effects of system response delays on elderly humans’ cognitive performance in a virtual training scenario
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Iconicity in Cognition and Communication
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In: Historical Social Research, Supplement ; 31 ; 66-77 ; Models and Modelling between Digital & Humanities - A Multidisciplinary Perspective (2019)
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Soziologie der Steinzeit - die Anfänge des Denkens von der Höhlenmalerei zur Hochkultur am Göbekli Tepe
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Lenguaje y referencia ; Language and reference
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In: Sophia : colección de filosofía de la educación. - (2019) , 141-166, ISSN: 1390-3861 (2019)
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