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A unified model of post-stroke language deficits including discourse production and their neural correlates.
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Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity.
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Analyzing speech in both time and space : generalized additive mixed models can uncover systematic patterns of variation in vocal tract shape in real-time MRI
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Examining Brain Connectivity and Reading Ability in Children
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In: Electronic Thesis and Dissertation Repository (2020)
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Predicting early post-stroke aphasia outcome from initial aphasia severity
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Bedetti, Christophe; Rochon, Elizabeth; Leonard, Carol; Brisebois, Amélie; Brambati, Simona Maria; Osa Garcia, Alberto; Desautels, Alex; Désilets-Barnabé, Marianne; Marcotte, Karine. - : Frontiers media, 2020
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Abstract:
Background: The greatest degree of language recovery in post-stroke aphasia takes place within the first weeks. Aphasia severity and lesion measures have been shown to be good predictors of long-term outcomes. However, little is known about their implications in early spontaneous recovery. The present study sought to determine which factors better predict early language outcomes in individuals with post-stroke aphasia. Methods: Twenty individuals with post-stroke aphasia were assessed <72 h (acute) and 10–14 days (subacute) after stroke onset. We developed a composite score (CS) consisting of several linguistic sub-tests: repetition, oral comprehension and naming. Lesion volume, lesion load and diffusion measures [fractional anisotropy (FA) and axial diffusivity (AD)] from both arcuate fasciculi (AF) were also extracted using MRI scans performed at the same time points. A series of regression analyses were performed to predict the CS at the second assessment. Results: Among the diffusion measures, only FA from right AF was found to be a significant predictor of early subacute aphasia outcome. However, when combined in two hierarchical models with FA, age and either lesion load or lesion size, the initial aphasia severity was found to account for most of the variance (R 2 = 0.678), similarly to the complete models (R 2 = 0.703 and R 2 = 0.73, respectively). Conclusions: Initial aphasia severity was the best predictor of early post-stroke aphasia outcome, whereas lesion measures, though highly correlated, show less influence on the prediction model. We suggest that factors predicting early recovery may differ from those involved in long-term recovery.
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Keyword:
Aphasia; dMRI (diffusion magnetic resonance imaging); Early recovery; Linguistic assessment; Stroke; White matter (WM)
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URL: https://doi.org/10.3389/fneur.2020.00120 http://hdl.handle.net/1866/23908
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Neuro-Clinical Signatures of Language Impairments after Acute Stroke: A VBQ Analysis of Quantitative Native CT Scans.
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In: Current topics in medicinal chemistry, vol. 20, no. 9, pp. 792-799 (2020)
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First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
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Aphasia outcome: the interactions between initial severity, lesion size and location
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In: ISSN: 0340-5354 ; EISSN: 1432-1459 ; Journal of Neurology ; https://hal.inria.fr/hal-02418331 ; Journal of Neurology, Springer Verlag, 2019, 266 (6), pp.1303-1309. ⟨10.1007/s00415-019-09259-3⟩ (2019)
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Decline in verbal fluency after subthalamic nucleus deep brain stimulation in Parkinson's disease: a microlesion effect of the electrode trajectory?
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In: ISSN: 1877-718X ; EISSN: 1877-7171 ; Journal of Parkinson's disease ; https://hal-normandie-univ.archives-ouvertes.fr/hal-02373059 ; Journal of Parkinson's disease, Amsterdam : b : IOS Press, 2019, 5 (1), pp.95-104. ⟨10.3233/JPD-140443⟩ (2019)
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Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
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Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
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Increased cortical reactivity to repeated tones at 8 months in infants with later ASD. ...
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Transient Neurologic Deficit without Vascular Pathology Correlates with Reversible Focal Hypoperfusion on Arterial Spin Labeled Perfusion Imaging
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In: Author (2019)
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Balancing Prediction and Sensory Input in Speech Comprehension: The Spatiotemporal Dynamics of Word Recognition in Context. ...
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Domain-general and domain-specific computations in single word processing. ...
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Paracingulate Sulcus Morphology and Hallucinations in Clinical and Nonclinical Groups. ...
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Prediction of the Outcome of Cochlear Implantation in the Patients with Congenital Cytomegalovirus Infection based on Magnetic Resonance Imaging Characteristics
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In: Journal of Clinical Medicine ; Volume 8 ; Issue 2 (2019)
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Mechanisms for Auditory Perception: A Neurocognitive Study of Second Language Learning of Mandarin Chinese
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In: Brain Sciences ; Volume 9 ; Issue 6 (2019)
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Breastfeeding Duration Is Associated with Regional, but Not Global, Differences in White Matter Tracts
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In: Brain Sciences ; Volume 10 ; Issue 1 (2019)
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