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Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia. ...
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The neural systems supporting human intelligence, as measured by lesion analysis, task activation, and resting state connectivity
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| 63 |
Paracingulate Sulcus Morphology and Hallucinations in Clinical and Nonclinical Groups.
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| 64 |
Domain-general and domain-specific computations in single word processing.
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| 65 |
Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia.
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| 66 |
Balancing Prediction and Sensory Input in Speech Comprehension: The Spatiotemporal Dynamics of Word Recognition in Context.
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| 67 |
Increased cortical reactivity to repeated tones at 8 months in infants with later ASD.
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| 68 |
Differential language network functional connectivity alterations in Alzheimer's disease and the semantic variant of primary progressive aphasia
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| 69 |
Relación entre destreza musical y lateralización derecha del lenguaje en población zurda
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| 70 |
Anomalous morphology in left hemisphere motor and premotor cortex of children who stutter
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| 71 |
Anterior insular thickness predicts speech sound learning ability in bilinguals.
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In: NeuroImage, vol 165 (2018)
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| 72 |
Evidence Supporting LI-RADS Major Features for CT- and MR Imaging-based Diagnosis of Hepatocellular Carcinoma: A Systematic Review.
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In: Radiology, vol 286, iss 1 (2018)
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| 73 |
Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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| 75 |
Neuroscientific insights into the development of analogical reasoning.
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In: Developmental science, vol 21, iss 2 (2018)
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| 76 |
Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
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In: Nature neuroscience, vol 21, iss 12 (2018)
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Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
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In: Nature neuroscience, vol 21, iss 12 (2018)
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Brain basis of cognitive resilience: Prefrontal cortex predicts better reading comprehension in relation to decoding.
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In: PloS one, vol 13, iss 6 (2018)
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Dynamic integration of conceptual information during learning.
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In: PloS one, vol 13, iss 11 (2018)
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Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study
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In: ISSN: 1421-9824 ; Dementia and geriatric cognitive disorders ; https://hal.univ-angers.fr/hal-02869144 ; Dementia and geriatric cognitive disorders, 2018, 45, pp.18-26. ⟨10.1159/000485793⟩ ; https://www.karger.com/Article/Abstract/485793 (2018)
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Abstract:
International audience ; BACKGROUND: Vitamin K antagonists (VKAs) are commonly used for their role in haemostasis by interfering with the vitamin K cycle. Since vitamin K also participates in brain physiology, this voxel-based morphometric study aimed to determine whether the duration of exposure to VKAs correlated with focal brain volume reduction in older adults. METHODS: In this exposed/unexposed (1: 2) study nested within the GAIT (Gait and Alzheimer Interactions Tracking) cohort, 18 participants exposed to VKA (mean age 75 ± 5 years; 33.3% female; mean exposure 2,122 ± 1,799 days) and 36 matched participants using no VKA (mean age 75 ± 5 years; 33.3% female) underwent MRI scanning of the brain. Cortical grey and white matter volumes were automatically segmented using statistical parametric mapping. Age, gender, educational level, history of atrial fibrillation, type of MRI, and total intracranial volume were included as covariables. RESULTS: The duration of exposure to VKA correlated inversely across the whole brain with the subvolumes of two clusters in the grey matter (right frontal inferior operculum and right precuneus) and one cluster in the white matter (left middle frontal gyrus). In contrast, the grade of white matter hyperintensities did not differ according to the use of VKA. CONCLUSION: We found focal atrophies in older adults exposed to VKA. These findings provide new insights elucidating the effects of VKAs on brain health and function in older adults.
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Keyword:
80 and over; [SHS]Humanities and Social Sciences; Age Factors; Aged; Alzheimer Disease; Anticoagulants; Brain; Cohort Studies; Computer-Assisted; Cross-Sectional Studies; Educational Status; Female; Gait Disorders; Gray Matter; Humans; Image Processing; Magnetic Resonance Imaging; Male; Neurologic; Sex Factors; Vitamin K; White Matter
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URL: https://hal.univ-angers.fr/hal-02869144
https://doi.org/10.1159/000485793
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