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Label definitions augmented interaction model for legal charge prediction
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In: https://link.springer.com/book/10.1007/978-3-030-72113-8 (2021)
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DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China
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The trans-ancestral genomic architecture of glycemic traits.
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The trans-ancestral genomic architecture of glycemic traits.
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In: Nature genetics, vol. 53, no. 6, pp. 840-860 (2021)
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Are the protective benefits of vitamin D in neurodegenerative disease dependent on route of administration? A systematic review
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In: https://www-tandfonline-com.proxy.library.adelaide.edu.au/doi/full/10.1080/1028415X.2018.1493807 (2020)
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Abstract:
Background: The clinical and preclinical exploration of the therapeutic properties of vitamin D have significantly increased in the past decade, owing to the growing associative evidence suggesting vitamin D is neuroprotective. However, whether depletion of vitamin D contributes to the onset of neurological disorders or is a symptom of neurological disease has yet to be defined. Much remains unclear about the causal role of vitamin D and the method of use and forms of vitamin D. Objectives: We sought to quantitatively assess if neuroprotective benefits from vitamin D in neurodegenerative diseases are dependent on route of administration: comparing the effect of endogenously sourced vitamin D from UV exposure to exogenously derived vitamin D through synthetic supplementation. Design: We systematically searched PubMed, Embase and PsycInfo databases which included both pre-clinical and clinical studies investigating vitamin D in neurodegenerative diseases. Articles were subject to strict inclusion criteria and objectively assessed for quality. Additionally, Medline data was analysed to identify trends in topic publications and linguistic characteristics of papers. Results: From a total of 231 screened articles, we identified 73 appropriate for review based on inclusion criteria: original studies that investigated vitamin D levels or levels of vitamin D supplementation in neurodegenerative diseases or investigated past/present sun exposure in disease cohorts. Results indicate there is insufficient evidence to comprehensively reflect on a potential neuroprotective role for vitamin D and if this was dependent on route of administration. The majority of current data supporting neuroprotective benefits from vitamin D are based on pre-clinical and observational studies. Solid evidence is lacking to support the current hypothesis that the beneficial effect of UV exposure results from the synthesis of vitamin D. Sun exposure, independent of vitamin D production, may be protective against multiple Sclerosis, Parkinson’s disease and Alzheimer’s disease. Yet, further research is required to elucidate the beneficial mechanism of actions of UV exposure. The literature of vitamin D and amyotrophic lateral sclerosis was limited, and no conclusions were drawn. Therefore, in cases where UV-derived vitamin D was hypothesized to be the beneficial mediator in the neuroprotective effects of sun exposure, we propose results are based only on associative evidence. Conclusion: On the basis of this systematic review, strong recommendations regarding therapeutic benefits of vitamin D in neurodegenerative disease cannot be made. It is unclear if vitamin D mediates a protective benefit in neurodegenerative disease or whether it is an associative marker of UV exposure, which may contribute to as of yet unidentified neuroprotective factors. ; Krystal Iacopetta, Lyndsey E. Collins-Praino, Femke T. A. Buisman-Pijlman, Jiajun Liu, Amanda D. Hutchinson, Mark R. Hutchinson
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Keyword:
neurodegenerative disease; neuroprotection; sunlight; supplementation; systematic review; Vitamin D
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URL: http://hdl.handle.net/2440/118948
https://doi.org/10.1080/1028415X.2018.1493807
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Prescribing competency assessment for Canadian medical students: a pilot evaluation
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Native-speakerism in ELT: A case study of English language education in China
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The Next Frontier in Communication and the ECLIPPSE Study: Bridging the Linguistic Divide in Secure Messaging
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In: Schillinger, D; McNamara, D; Crossley, S; Lyles, C; Moffet, HH; Sarkar, U; et al.(2017). The Next Frontier in Communication and the ECLIPPSE Study: Bridging the Linguistic Divide in Secure Messaging. JOURNAL OF DIABETES RESEARCH. doi:10.1155/2017/1348242. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0384j5vf (2017)
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A comparative study of students' strategy use in reading texts for the IELTS test and those for academic study
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Evaluation of statistical text normalisation techniques for Twitter
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Evaluation of statistical text normalisation techniques for Twitter
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Evaluation of statistical text normalisation techniques for Twitter
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| 14 |
How does studying abroad change Chinese students' choice of reading strategies?
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Liu, J.. - : University of Toronto Press, 2016
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Methods for conducting systematic reviews of risk factors in low- and middle-income countries
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Social touch gesture recognition using random forest and boosting on distinct feature sets
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Reading transition in Chinese international students: through the lens of activity system theory
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Physical activity during pregnancy and language development in the offspring
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A statistical study on ELF-whistlers/emissions and M ≥ 5.0 earthquakes in Taiwan
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