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1
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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2
Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism
In: Journal of Clinical Medicine; Volume 11; Issue 8; Pages: 2260 (2022)
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3
Pilotstudie zur parodontalen Gesundheit bei Patienten mit frontotemporaler Demenz ...
Baumgartner, Monika. - : Universität Ulm, 2022
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4
A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
Patel, Nikil; Peterson, Katie A; Ingram, Ruth U. - : Apollo - University of Cambridge Repository, 2022
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5
A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
Patel, Nikil; Peterson, Katie A; Ingram, Ruth U. - : Apollo - University of Cambridge Repository, 2022
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6
Temporal cognition: subjective time and its connection with memory in frontotemporal dementia
Liu, Lulu. - : The University of Sydney, 2022. : Faculty of Science, School of Psychology, 2022
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7
Improving the diagnostic accuracy of primary progressive aphasia using cognitive tests
Foxe, David Gordon. - : The University of Sydney, 2022. : Faculty of Science, School of Psychology, 2022
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8
Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
Abstract: International audience ; OBJECTIVE: To determine relative frequencies and linguistic profiles of primary progressive aphasia (PPA) variants associated with progranulin (GRN) mutations, and study their neuroanatomical correlates. METHODS: PPA patients carrying GRN mutations (PPA-GRN) were selected amongst a national prospective research cohort of 1,696 frontotemporal dementia (FTD) patients, including 235 patients with PPA. All PPA patients with amyloid-positive CSF biomarkers were excluded. In this cross-sectional study, speech/language and cognitive profiles were characterized with standardized evaluations, and grey matter (GM) atrophy patterns using voxel-based morphometry. Comparisons were performed with controls, and sporadic PPA patients. RESULTS: Among the overall population of 235 patients, 45 (19%) carried GRN mutations. We studied 32 of these and showed that logopenic PPA (lvPPA) was the most frequent linguistic variant (13, 41%), followed by non-fluent/agrammatic (nfvPPA: 9, 28%) and mixed forms (8, 25%). Semantic variant was rather rare (2, 6%). LvPPA patients, qualified as non-amyloid-lvPPA, presented canonical logopenic deficit. Seven out of 13 had a pure form, six showed subtle additional linguistic deficits not fitting criteria for mixed PPA, hence labelled as "logopenic-spectrum variant". GM atrophy primarily involved left posterior temporal gyrus, mirroring neuroanatomical changes of amyloid-positive-lvPPA. NfvPPA patients presented agrammatism (89%) rather than apraxia of speech (11%). CONCLUSIONS: This study shows that most frequent PPA variant associated with GRN mutations is non-amyloid lvPPA, preceding nfvPPA and mixed forms, and illustrates that language network may be affected at different levels. GRN testing is indicated for PPA patients, whether familial or sporadic. This finding is important for upcoming GRN gene-specific therapies.
Keyword: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Dementia aphasia; Frontotemporal dementia
URL: https://hal.archives-ouvertes.fr/hal-03281660/document
https://hal.archives-ouvertes.fr/hal-03281660/file/NEUROLOGY-2020-153064v3-LeBer.pdf
https://hal.archives-ouvertes.fr/hal-03281660
https://doi.org/10.1212/wnl.0000000000012174
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9
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021
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10
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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11
Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults.
Rankin, Katherine P; Toller, Gianina; Gavron, Lauren. - : eScholarship, University of California, 2021
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12
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021
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13
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
Magrath Guimet, Nahuel; Miller, Bruce L; Allegri, Ricardo F. - : eScholarship, University of California, 2021
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14
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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15
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
Magrath Guimet, Nahuel; Miller, Bruce L; Allegri, Ricardo F. - : eScholarship, University of California, 2021
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16
Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia. ...
Benussi, Alberto; Alberici, Antonella; Samra, Kiran. - : Apollo - University of Cambridge Repository, 2021
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17
Application of Machine Learning to Electroencephalography for the Diagnosis of Primary Progressive Aphasia: A Pilot Study
In: Brain Sciences ; Volume 11 ; Issue 10 (2021)
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18
Verbal Short-Term Memory Disturbance in the Primary Progressive Aphasias: Challenges and Distinctions in a Clinical Setting
In: Brain Sciences ; Volume 11 ; Issue 8 (2021)
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19
Cognitive and Neural Mechanisms of Social Communication Dysfunction in Primary Progressive Aphasia
In: Brain Sciences; Volume 11; Issue 12; Pages: 1600 (2021)
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20
Semantic Variant Primary Progressive Aphasia: Practical Recommendations for Treatment from 20 Years of Behavioural Research
In: Brain Sciences ; Volume 11 ; Issue 12 (2021)
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