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Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
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In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
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Providing a parent-administered outcome measure in a bilingual family of a father and a mother of two adolescents with ASD: brief report.
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In: Developmental neurorehabilitation, vol 25, iss 2 (2022)
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Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences—A Narrative Review
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In: International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3932 (2022)
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| 4 |
Artificial Intelligence Enabled Personalised Assistive Tools to Enhance Education of Children with Neurodevelopmental Disorders—A Review
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In: International Journal of Environmental Research and Public Health; Volume 19; Issue 3; Pages: 1192 (2022)
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| 7 |
Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
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| 8 |
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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| 9 |
Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation.
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In: Human brain mapping, vol 42, iss 14 (2021)
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Abstract:
The importance of (inherited) genetic impact in reading development is well established. De novo mutation is another important contributor that is recently gathering interest as a major liability of neurodevelopmental disorders, but has been neglected in reading research to date. Paternal age at childbirth (PatAGE) is known as the most prominent risk factor for de novo mutation, which has been repeatedly shown by molecular genetic studies. As one of the first efforts, we performed a preliminary investigation of the relationship between PatAGE, offspring's reading, and brain structure in a longitudinal neuroimaging study following 51 children from kindergarten through third grade. The results showed that greater PatAGE was significantly associated with worse reading, explaining an additional 9.5% of the variance after controlling for a number of confounds-including familial factors and cognitive-linguistic reading precursors. Moreover, this effect was mediated by volumetric maturation of the left posterior thalamus from ages 5 to 8. Complementary analyses indicated the PatAGE-related thalamic region was most likely located in the pulvinar nuclei and related to the dorsal attention network by using brain atlases, public datasets, and offspring's diffusion imaging data. Altogether, these findings provide novel insights into neurocognitive mechanisms underlying the PatAGE effect on reading acquisition during its earliest phase and suggest promising areas of future research.
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Keyword:
2.1 Biological and endogenous factors; Basic Behavioral and Social Science; Behavioral and Social Science; Brain Disorders; Cognitive Sciences; dorsal attention network; dyslexia; Experimental Psychology; Genetics; longitudinal design; Mental Health; Neurological; Neurosciences; paternal age; Pediatric; pulvinar nuclei; reading
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URL: https://escholarship.org/uc/item/9sk3n80g
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| 10 |
Providing a parent-administered outcome measure in a bilingual family of a father and a mother of two adolescents with ASD: brief report.
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| 11 |
Pre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism.
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In: Molecular psychiatry, vol 26, iss 12 (2021)
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| 12 |
A Therapeutic Relational Agent for Reducing Problematic Substance Use (Woebot): Development and Usability Study.
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In: Journal of medical Internet research, vol 23, iss 3 (2021)
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| 13 |
A systematic review of cognitive behavior therapy and dialectical behavior therapy for adolescent eating disorders.
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In: Journal of eating disorders, vol 9, iss 1 (2021)
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| 14 |
Concurrent Associations between Expressive Language Ability and Independence in Adolescents and Adults with Fragile X Syndrome.
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In: Brain sciences, vol 11, iss 9 (2021)
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| 15 |
Concurrent Associations between Expressive Language Ability and Independence in Adolescents and Adults with Fragile X Syndrome.
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In: Brain sciences, vol 11, iss 9 (2021)
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| 16 |
Artificial Intelligence for Mental Health Care: Clinical Applications, Barriers, Facilitators, and Artificial Wisdom.
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In: Biological psychiatry. Cognitive neuroscience and neuroimaging, vol 6, iss 9 (2021)
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| 18 |
Characteristics and Impacts of Community Aphasia Group Facilitation - A Systematic Scoping Review ...
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| 19 |
Next-gen sequencing identifies non-coding variation disrupting miRNA-binding sites in neurological disorders
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| 20 |
Dialectical Behavior Therapy for Dual Diagnosis: Treating Adolescent Substance Use Disorder and Co-Occurring Mood Disorders
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In: Senior Honors Projects (2021)
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