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81
Cerebral dominance for language function in adults with specific language impairment or autism
Whitehouse, Andrew J. O.; Bishop, Dorothy V. M.. - : Oxford University Press, 2008
Abstract: A link between developmental language disorders and atypical cerebral lateralization has been postulated since the 1920s, but evidence has been indirect and inconsistent. The current study investigated this proposal using functional transcranial Doppler ultrasonography (fTCD), which assesses blood flow through the middle cerebral arteries serving the left and right cerebral hemispheres. A group of young adults with specific language impairment (SLI; n = 11) were recruited along with three comparison groups: (i) adults with a history of childhood SLI, but who did not meet criteria for language impairment in adulthood (SLI-history; n = 9); (ii) adults with an autism spectrum disorder and a comorbid language impairment (ASD; n = 11) and (iii) adults with no history of developmental disorder (typical; n = 11). There was no difference between the chronological age of the four groups, and the SLI and typical groups were individually matched on gender and handedness. During fTCD measurement, participants were asked to silently generate words starting with a given letter and then later required to verbalize these. All of the participants in the SLI-history group and the majority of participants in the ASD (81.8%) and typical (90.9%) groups had greater activation in the left compared to the right middle cerebral arteries, indicating left hemisphere dominance. In contrast, the majority of participants in the SLI groups had language function lateralized to the right hemisphere (54.5%) or dispersed bilaterally (27.3%). These findings suggest that atypical cerebral dominance is not implicated in all cases of poor language development (i.e. ASD and SLI-history groups), but may act as a biological marker of persisting SLI.
Keyword: Original Articles
URL: http://brain.oxfordjournals.org/cgi/content/short/131/12/3193
https://doi.org/10.1093/brain/awn266
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82
Cerebral dominance for language function in adults with specific language impairment or autism
Whitehouse, Andrew J. O.; Bishop, Dorothy V. M.. - : Oxford University Press, 2008
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83
Autism and diagnostic substitution: evidence from a study of adults with a history of developmental language disorder
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84
Do children with autism 'switch off' to speech sounds? An investigation using event-related potentials
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85
Cerebral dominance for language function in adults with specific language impairment or autism
Whitehouse, Andrew J. O.; Bishop, Dorothy V. M.. - : Oxford University Press, 2008
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86
Forty years on: Uta Frith's contribution to research on autism and dyslexia, 1966–2006
Bishop, Dorothy V. M.. - : Psychology Press Taylor & Francis Group, 2008
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87
The broader language phenotype of autism: a comparison with specific language impairment
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88
Effect of attentional state on frequency discrimination: a comparison of children with ADHD on and off medication
In: Journal of speech, language, and hearing research. - Rockville, Md. : American Speech-Language-Hearing Association 49 (2006) 5, 1072-1084
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89
Hearing - Articles and Reports - Effect of Attentional State on Frequency Discrimination: A Comparison of Children With ADHD On and Off Medication
In: Journal of speech, language, and hearing research. - Rockville, Md. : American Speech-Language-Hearing Association 49 (2006) 5, 1072
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90
Resistance of grammatical impairment to computerized comprehension training in children with specific and non-specific language impairments
In: International journal of language & communication disorders. - Oxford : Wiley-Blackwell 41 (2006) 1, 19-40
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91
Is poor frequency modulation detection linked to literacy problems? : A comparison of specific reading disability and mild to moderate sensorineural hearing loss
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 97 (2006) 2, 200-213
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92
A case of exceptional reading accuracy in a child with Down syndrome : underlying skills and the relation to reading comprehension
In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 23 (2006) 8, 1190-1214
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93
Psychophysical indices of perceptual functioning in dyslexia : a psychometric analysis
In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 23 (2006) 6, 905-929
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94
Auditory frequency discrimination in children with dyslexia
In: Journal of research in reading. - Leeds : Wiley-Blackwell 29 (2006) 2, 213-228
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95
Common aetiology for diverse language skills in 41/2-year-old twins
In: Journal of child language. - Cambridge [u.a.] : Cambridge Univ. Press 33 (2006) 2, 339-368
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96
Beyond words: Phonological short-term memory and syntactic impairment in specific language impairment
In: Applied psycholinguistics. - Cambridge [u.a.] : Cambridge Univ. Press 27 (2006) 4, 545
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97
Hemispheric Specialization for Processing Auditory Nonspeech Stimuli
Jamison, Helen L.; Watkins, Kate E.; Bishop, Dorothy V. M.. - : Oxford University Press, 2006
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98
Hemispheric specialization for processing auditory nonspeech stimuli
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99
What causes specific language impairment in children?
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100
Developmental cognitive genetics: how psychology can inform genetics and vice versa
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