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Evidence for overuse of cardiovascular healthcare services in high-income countries: protocol for a systematic review and meta-analysis
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In: BMJ Open (2022)
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Different Rates of Bioprosthetic Aortic Valve Failure With Perimount™ and Trifecta™ Bioprostheses
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In: Front Cardiovasc Med (2022)
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Switching of oral anticoagulants in atrial fibrillation: a cohort study using Australian general practice data
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Potencialidades do estudo contextualizado do sistema cardiovascular para o desenvolvimento da linguagem científica
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Molecular Epidemiology of G6PD Genotypes in Different Ethnic Groups Residing in Saharan and Sahelian Zones of Mauritania
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In: ISSN: 2076-0817 ; Pathogens ; https://hal-amu.archives-ouvertes.fr/hal-03429269 ; Pathogens, MDPI, 2021, 10 (8), pp.931. ⟨10.3390/pathogens10080931⟩ (2021)
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Associations between Cardiovascular Signal Entropy and Cognitive Performance over Eight Years
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In: Entropy ; Volume 23 ; Issue 10 (2021)
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Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets
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In: Front Cardiovasc Med (2021)
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Oral, Tongue-Coating Microbiota, and Metabolic Disorders: A Novel Area of Interactive Research
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In: Front Cardiovasc Med (2021)
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Respiratory Sinus Arrhythmia in Children—Predictable or Random?
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In: Front Cardiovasc Med (2021)
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Utility of blood pressure measurements at an initial screening visit to identify Chinese children and adolescents with hypertension
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Switching of oral anticoagulants in patients with nonvalvular atrial fibrillation: A narrative review
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Psychophysiological Responses to Acute Cold Water Immersion
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Implementation of cascade genetic screening for familial hypercholesterolemia: Design of the Swiss catch randomized controlled trial
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Nanchen, D.; Von Känel, T.; Brun, N.; Sudano, I.; Rickli, H.; Ehret, G.; Girod, G.; Del Giorno, R.; Rodondi, N.; Beer, J.H.; Gallino, A.
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In: EAS 2021 abstracts : European Atherosclerosis Society, vol. 331, pp. e184 (2021)
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Abstract:
Background and Aims: The large-scale implementation and effectiveness of genetic cascade screening for familial hypercholesterolemia (FH) has been poorly studied. Based on web technologies, we aim to study a contemporary method to contact relatives to improve detection of FH. Methods: Adults with a Dutch Lipid Clinic Network score of 6 or more points will be screened. Once a pathogenic variant in the LDLR, APOB, or PCSK9 gene will be identified, several cycles of cascade will identify first, second, and third-degree relatives. Compared to usual care, the intervention group will receive prepared email or SMS to be sent to relatives. By clicking in the text, the relative can then provide agreement to be contacted by one of the study center. The primary outcome is the difference in the yield of detection of FH between study groups. The yield of detection is the number of genetic test performed/number of contactable relatives. Secondary outcomes are changes in health behaviors, LDL-c levels and lipid-lowering drugs over 6-months. Results: Overall, 56 families need to be included to show a significant difference of 20% in the yield of detection between the control (20%) and interventional group (40%), assuming 4 contactable relatives per family. A study network of lipid and cardiovascular clinics has been created in all linguistic regions of Switzerland. A biobank of DNA samples with family link will allow further assessment of genetic causes of dyslipidemia. Conclusions: This large-scale implementation study will provide new evidence regarding public health, societal and clinical effectiveness of genetic cascade screening for FH.
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Keyword:
Cardiology and Cardiovascular Medicine
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URL: https://serval.unil.ch/notice/serval:BIB_9EE9DF76C8BC https://doi.org/10.1016/j.atherosclerosis.2021.06.562
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Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease
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Minimizing the duration of laser Doppler flowmetry recordings while maintaining wavelet analysis quality: A methodological study
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In: ISSN: 0026-2862 ; EISSN: 1095-9319 ; Microvascular Research ; https://hal-univ-avignon.archives-ouvertes.fr/hal-03291993 ; Microvascular Research, Elsevier, 2020, 131, ⟨10.1016/j.mvr.2020.104034⟩ (2020)
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Tropomyosin autoantibodies associated with checkpoint inhibitor myositis
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In: Research outputs 2014 to 2021 (2020)
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Factors that influence adherence to treatment plans amongst people living with cardiovascular disease: A review of published qualitative research studies
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In: Research outputs 2014 to 2021 (2020)
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Quality of life measured by EQ-5D at different treatment time points for coronary artery disease: protocol for a systematic review and meta-analysis
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Quality of life measured by EQ-5D at different treatment time points for coronary artery disease: protocol for a systematic review and meta-analysis
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In: BMJ Open (2020)
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