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1
Longitudinal changes in cortical responses to letter-speech sound stimuli in 8–11 year-old children
In: NPJ Sci Learn (2022)
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2
Cortical responses to letters and ambiguous speech vary with reading skills in dyslexic and typically reading children
In: Neuroimage Clin (2021)
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3
Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
In: ISSN: 1359-4184 ; EISSN: 1476-5578 ; Molecular Psychiatry ; https://hal.archives-ouvertes.fr/hal-02976104 ; Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-00898-x⟩ (2020)
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4
ERP mismatch response to phonological and temporal regularities in speech
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ERP mismatch response to phonological and temporal regularities in speech
In: Sci Rep (2020)
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
In: ISSN: 2158-3188 ; EISSN: 2158-3188 ; Translational Psychiatry ; https://hal.archives-ouvertes.fr/hal-02158502 ; Translational Psychiatry, Nature Pub. Group, 2019, 9, pp.77. ⟨10.1038/s41398-019-0402-0⟩ (2019)
Abstract: International audience ; Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N = 2562-3468). We observed a genome-wide significant effect (p < 1 × 10 −8) on rapid automatized naming of letters (RANlet) for variants on 18q12.2, within MIR924HG (micro-RNA 924 host gene; rs17663182 p = 4.73 × 10 −9), and a suggestive association on 8q12.3 within NKAIN3 (encoding a cation transporter; rs16928927, p = 2.25 × 10 −8). rs17663182 (18q12.2) also showed genome-wide significant multivariate associations with RAN measures (p = 1.15 × 10 −8) and with all the cognitive traits tested (p = 3.07 × 10 −8), suggesting (relational) pleiotropic effects of this variant. A polygenic risk score (PRS) analysis revealed significant genetic overlaps of some of the DD-related traits with educational attainment (EDUyears) and ADHD. Reading and spelling abilities were positively associated with EDUyears (p~[10 −5-10 −7 ]) and negatively associated with ADHD PRS (p[ 10 −8 −10 −17 ]). This corroborates a long-standing hypothesis on the partly shared genetic etiology of DD and ADHD, at the genome-wide level. Our findings suggest new candidate DD susceptibility genes and provide new insights into the genetics of dyslexia and its comorbities.
Keyword: [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics; [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
URL: https://hal.archives-ouvertes.fr/hal-02158502
https://doi.org/10.1038/s41398-019-0402-0
https://hal.archives-ouvertes.fr/hal-02158502/document
https://hal.archives-ouvertes.fr/hal-02158502/file/Gialluisi-et-al_TP2019.pdf
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7
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia ...
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8
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
In: Translational Psychiatry, 9 (1) (2019)
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9
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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10
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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11
Reading-Induced Shifts in Speech Perception in Dyslexic and Typically Reading Children
Romanovska, Linda; Janssen, Roef; Bonte, Milene. - : Frontiers Media S.A., 2019
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12
A Selective Deficit in Phonetic Recalibration by Text in Developmental Dyslexia
Keetels, Mirjam; Bonte, Milene; Vroomen, Jean. - : Frontiers Media S.A., 2018
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13
Reading-induced shifts of perceptual speech representations in auditory cortex
Bonte, Milene; Correia, Joao M.; Keetels, Mirjam. - : Nature Publishing Group UK, 2017
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14
Altered patterns of directed connectivity within the reading network of dyslexic children and their relation to reading dysfluency
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15
Decoding Articulatory Features from fMRI Responses in Dorsal Speech Regions
Correia, Joao M.; Jansma, Bernadette M.B.; Bonte, Milene. - : Society for Neuroscience, 2015
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16
EEG decoding of spoken words in bilingual listeners: from words to language invariant semantic-conceptual representations
Correia, João M.; Jansma, Bernadette; Hausfeld, Lars. - : Frontiers Media S.A., 2015
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17
Phonetic recalibration of speech by text
Keetels, Mirjam; Schakel, Lemmy; Bonte, Milene. - : Springer US, 2015
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18
Brain-Based Translation: fMRI Decoding of Spoken Words in Bilinguals Reveals Language-Independent Semantic Representations in Anterior Temporal Lobe
Correia, João; Formisano, Elia; Valente, Giancarlo. - : Society for Neuroscience, 2014
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19
The long road to automation: neurocognitive development of letter-speech sound processing
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 21 (2009) 3, 567-580
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20
'Who' is saying 'what'? Brain-based decoding of human voice and speech
In: Science. - Washington, DC : AAAS, American Assoc. for the Advancement of Science 322 (2008) 5903, 970-973
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