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The genetic architecture of language functional connectivity
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In: ISSN: 1053-8119 ; EISSN: 1095-9572 ; NeuroImage ; https://hal.sorbonne-universite.fr/hal-03566120 ; NeuroImage, Elsevier, 2022, 249, pp.118795. ⟨10.1016/j.neuroimage.2021.118795⟩ (2022)
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Abstract:
International audience ; Language is a unique trait of the human species, of which the genetic architecture remains largely unknown. Through language disorders studies, many candidate genes were identified. However, such complex and multifactorial trait is unlikely to be driven by only few genes and case-control studies, suffering from a lack of power, struggle to uncover significant variants. In parallel, neuroimaging has significantly contributed to the understanding of structural and functional aspects of language in the human brain and the recent availability of large scale cohorts like UK Biobank have made possible to study language via image-derived endophenotypes in the general population. Because of its strong relationship with task-based fMRI (tbfMRI) activations and its easiness of acquisition, resting-state functional MRI (rsfMRI) have been more popularised, making it a good surrogate of functional neuronal processes. Taking advantage of such a synergistic system by aggregating effects across spatially distributed traits, we performed a multivariate genome-wide association study (mvGWAS) between genetic variations and resting-state functional connectivity (FC) of classical brain language areas in the inferior frontal (pars opercularis, triangularis and orbitalis), temporal and inferior parietal lobes (angular and supramarginal gyri), in 32,186 participants from UK Biobank. Twenty genomic loci were found associated with language FCs, out of which three were replicated in an independent replication sample. A locus in 3p11.1, regulating EPHA3 gene expression, is found associated with FCs of the semantic component of the language network, while a locus in 15q14, regulating THBS1 gene expression is found associated with FCs of the perceptual-motor language processing, bringing novel insights into the neurobiology of language.
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Keyword:
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; GWAS; Imaging-genetics; Language; Multivariate analysis; Resting-state functional MRI; UK Biobank
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URL: https://hal.sorbonne-universite.fr/hal-03566120/file/1-s2.0-S1053811921010661-main.pdf
https://hal.sorbonne-universite.fr/hal-03566120/document
https://hal.sorbonne-universite.fr/hal-03566120
https://doi.org/10.1016/j.neuroimage.2021.118795
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| 2 |
Psychiatry on Twitter: Content Analysis of the Use of Psychiatric Terms in French
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In: ISSN: 2561-326X ; JMIR Formative Research ; https://hal.archives-ouvertes.fr/hal-03614832 ; JMIR Formative Research, JMIR Publications 2022, 6 (2), pp.e18539. ⟨10.2196/18539⟩ ; https://formative.jmir.org/2022/2/e18539 (2022)
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| 3 |
Apodictic discourse and the Cauchy-Bunyakovsky-Schwarz inequality ; Discours apodictique et inégalité de Cauchy-Bunyakovsky-Schwarz
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In: ISSN: 0970-0307 ; Ganita Bharati (Indian Mathematics): Journal of the Indian Society for History of Mathematics ; https://hal.archives-ouvertes.fr/hal-03643571 ; Ganita Bharati (Indian Mathematics): Journal of the Indian Society for History of Mathematics, Prints Publications Pvt., In press (2022)
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| 4 |
Meta-Analysis of the Functional Neuroimaging Literature with Probabilistic Logic Programming
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In: https://hal.archives-ouvertes.fr/hal-03590714 ; 2022 (2022)
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| 5 |
Within and Beyond Stereotypes of Arab Women: A Corpus-based Approach to Jordanian Women’s Portrayal in English Digital News
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In: Journal of International Women's Studies (2022)
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| 6 |
From "violence against women" to "violence against women and girls". The reconceptualisation of violence against women in United-Nations discourse
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In: ISSN: 0960-4545 ; EISSN: 2518-3567 ; The European English Messenger ; https://hal.archives-ouvertes.fr/hal-03587067 ; The European English Messenger, European Society for the Study of English ESSE, 2022 (2022)
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| 7 |
Professional Testimony: Construction and Analysis of a “Graphic Object” in a Physics Class in a 12th Grade Science Major
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In: Objects to Learn About and Objects for Learning 1 ; https://hal.archives-ouvertes.fr/hal-03589558 ; Joël Bisault, Roselyne Le Bourgeois, Jean-François Thémines, Mickaël Le Mentec, Céline Chauvet-Chanoine. Objects to Learn About and Objects for Learning 1, Wiley, 2022, Online ISBN: 9781119902171 Print ISBN: 9781786306715. ⟨10.1002/9781119902171.ch5⟩ (2022)
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| 8 |
Pragmatique de l’insulte en politique : l’art d’accuser l’autre ou la performativité en perspective
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In: Les usages politiques de l'insulte ; https://halshs.archives-ouvertes.fr/halshs-03648831 ; Cédric Passard, Sciences Po, Lille. Les usages politiques de l'insulte, A paraître (2022)
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| 9 |
"What It Means to Discriminate". Presentation of The Volume ; « Ce que discriminer veut dire ». Présentation du volume
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In: ISSN: 1638-5748 ; EISSN: 1638-573X ; CORELA - COgnition, REprésentation, LAngage ; https://halshs.archives-ouvertes.fr/halshs-03648818 ; CORELA - COgnition, REprésentation, LAngage, CERLICO-Cercle Linguistique du Centre et de l'Ouest (France), 2022, ⟨10.4000/corela.14510⟩ (2022)
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| 10 |
Psychological Well-Being of Left-Behind Children in China: Text Mining of the Social Media Website Zhihu.
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In: International journal of environmental research and public health, vol 19, iss 4 (2022)
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| 11 |
On the recognitionality of references to time in social interaction
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| 12 |
Speaking Style Variability in Speaker Discrimination by Humans and Machines
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| 13 |
VEREINDEUTIGUNG ZUR KLASSIFIZIERUNG LEXIKALISCHER OBJEKTE ; DISAMBIGUATION FOR THE CLASSIFICATION OF LEXICAL ITEMS ; DÉSAMBÏGUISATION POUR LA CLASSIFICATION DE LEXÈMES
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In: https://hal.archives-ouvertes.fr/hal-03598242 ; France, Patent n° : EP3937059A1. 2022 (2022)
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| 14 |
PROTECT: A Pipeline for Propaganda Detection and Classification
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In: CLiC-it 2021- Italian Conference on Computational Linguistics ; https://hal.archives-ouvertes.fr/hal-03417019 ; CLiC-it 2021- Italian Conference on Computational Linguistics, Jan 2022, Milan, Italy (2022)
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| 15 |
Cyberhate in the Context of Migrations
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In: https://hal.archives-ouvertes.fr/hal-03572743 ; Springer International Publishing, 2022, 978-3-030-92105-7. ⟨10.1007/978-3-030-92103-3⟩ ; https://link.springer.com/book/10.1007/978-3-030-92103-3 (2022)
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| 16 |
Evaluating multimodal literacy: Academic and professional interactions around student-produced instructional video tutorials
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In: ISSN: 0346-251X ; System ; https://hal.archives-ouvertes.fr/hal-03521668 ; System, Elsevier, 2022, 105, pp.102727. ⟨10.1016/j.system.2022.102727⟩ (2022)
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| 17 |
Chapter 11. Consumer opinion about smoked bacon using Twitter and textual analysis: The challenge continues
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In: Sensory Analysis for the Development of Meat Products ; https://hal-agrosup-dijon.archives-ouvertes.fr/hal-03575175 ; Sensory Analysis for the Development of Meat Products, Elsevier, pp.181-196, 2022, 9780128228326. ⟨10.1016/B978-0-12-822832-6.00013-8⟩ (2022)
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| 18 |
Claiming epistemic access: 'Eh ciò'-prefaced turns in Trevigiano and in regional Italian
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In: ISSN: 0378-2166 ; EISSN: 1879-1387 ; Journal of Pragmatics ; https://hal.archives-ouvertes.fr/hal-03563222 ; Journal of Pragmatics, Elsevier, 2022, 190, pp.110-122. ⟨10.1016/j.pragma.2022.01.008⟩ (2022)
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| 19 |
Theater and Peacebuilding in Post-Conflict Settings: Participants’ Experiences in the Morning Star Theater Program in South Sudan
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In: Antioch University Full-Text Dissertations & Theses (2022)
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| 20 |
INGLIZ VA O'ZBEK TILLARIDA SINONIM SO'ZLARINING QIYOSIY TAXLILI ASNOSIDA LUG'AVIY ZAXIRANI RIVOJLANTIRISH ...
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