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Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
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Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration.
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Binney, Richard J; Pankov, Aleksandr; Marx, Gabriel; He, Xuanzie; McKenna, Faye; Staffaroni, Adam M; Kornak, John; Attygalle, Suneth; Boxer, Adam L; Schuff, Norbert; Gorno-Tempini, Maria-Luisa; Weiner, Michael W; Kramer, Joel H; Miller, Bruce L; Rosen, Howard J
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In: Brain and behavior, vol 7, iss 4 (2017)
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Abstract:
IntroductionLongitudinal imaging of neurodegenerative disorders is a potentially powerful biomarker for use in clinical trials. In Alzheimer's disease, studies have demonstrated that empirically derived regions of interest (ROIs) can provide more reliable measurement of disease progression compared with anatomically defined ROIs.MethodsWe set out to derive ROIs with optimal effect size for quantifying longitudinal change in a hypothetical clinical trial by comparing atrophy rates in 44 patients with behavioral variant of frontotemporal dementia (bvFTD), 30 with the semantic variant primary progressive aphasia (svPPA), and 26 with the nonfluent variant PPA (nfvPPA) to atrophy in 97 cognitively healthy controls.ResultsThe regions identified for each variant were generally what would be expected from prior studies of frontotemporal lobar degeneration (FTLD). Sample size estimates for detecting a 40% reduction in annual rate of ROI atrophy varied substantially across groups, being 103 per arm in bvFTD, 31 in nfvPPA, and 10 in svPPA, but in all groups were less than those estimated for a priori ROIs and clinical measures. The variability in location of peak regions of atrophy across individuals was highest in bvFTD and lowest in svPPA, likely relating to the differences in effect size.ConclusionsThese findings suggest that, while cross-validated maps of change can improve sensitivity to change in FTLD compared with a priori regions, the reliability of these maps differs considerably across syndromes. Future studies can utilize these maps to design clinical trials, and should try to identify factors accounting for the variability in patterns of atrophy across individuals, particularly those with bvFTD.
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Keyword:
Aged; Aphasia; Atrophy; Cognitive Sciences; Disease Progression; Female; frontotemporal dementia; Frontotemporal Lobar Degeneration; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Neurosciences; Primary Progressive; primary progressive aphasia; Psychology; Retrospective Studies
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URL: https://escholarship.org/uc/item/1xd9f3hr
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Observing conversational laughter in frontotemporal dementia.
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In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017)
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Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
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Observing conversational laughter in frontotemporal dementia.
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In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017)
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Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration.
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In: Brain and behavior, vol 7, iss 4 (2017)
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Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy.
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Clinicopathologic correlations and neuroimaging biomarkers in primary progressive aphasia
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In: TDX (Tesis Doctorals en Xarxa) (2017)
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Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants
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Visuospatial Functioning in the Primary Progressive Aphasias
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Typical and atypical pathology in primary progressive aphasia variants
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Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia
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Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia
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Clinicopathologic correlations and neuroimaging biomarkers in primary progressive aphasia
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