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Expressive language development in adolescents with Down syndrome and fragile X syndrome: change over time and the role of family-related factors.
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In: Journal of neurodevelopmental disorders, vol 12, iss 1 (2020)
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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A neurophysiological model of speech production deficits in fragile X syndrome.
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In: Brain communications, vol 2, iss 1 (2020)
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Screen time in 36-month-olds at increased likelihood for ASD and ADHD.
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Screen time in 36-month-olds at increased likelihood for ASD and ADHD.
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Molecular Biomarkers Predictive of Sertraline Treatment Response in Young Children With Autism Spectrum Disorder.
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A Therapeutic Relational Agent for Reducing Problematic Substance Use (Woebot): Development and Usability Study (Preprint)
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The Relationship between Expressive Language Sampling and Clinical Measures in Fragile X Syndrome and Typical Development.
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In: Brain sciences, vol 10, iss 2 (2020)
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Artificial intelligence approaches to predicting and detecting cognitive decline in older adults: A conceptual review.
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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Bigdeli, Tim B; Genovese, Giulio; Georgakopoulos, Penelope; Meyers, Jacquelyn L; Peterson, Roseann E; Iyegbe, Conrad O; Medeiros, Helena; Valderrama, Jorge; Achtyes, Eric D; Kotov, Roman; Stahl, Eli A; Abbott, Colony; Azevedo, Maria Helena; Belliveau, Richard A; Bevilacqua, Elizabeth; Bromet, Evelyn J; Byerley, William; Carvalho, Celia Barreto; Chapman, Sinéad B; DeLisi, Lynn E; Dumont, Ashley L; O'Dushlaine, Colm; Evgrafov, Oleg V; Fochtmann, Laura J; Gage, Diane; Kennedy, James L; Kinkead, Becky; Macedo, Antonio; Moran, Jennifer L; Morley, Christopher P; Dewan, Mantosh J; Nemesh, James; Perkins, Diana O; Purcell, Shaun M; Rakofsky, Jeffrey J; Scolnick, Edward M; Sklar, Brooke M; Sklar, Pamela; Smoller, Jordan W; Sullivan, Patrick F; Macciardi, Fabio; Marder, Stephen R; Gur, Ruben C; Gur, Raquel E; Braff, David L; Consortium on the Genetics of Schizophrenia (COGS) Investigators; Nicolini, Humberto; Escamilla, Michael A; Vawter, Marquis P; Sobell, Janet L; Malaspina, Dolores; Lehrer, Douglas S; Buckley, Peter F; Rapaport, Mark H; Knowles, James A; Genomic Psychiatry Cohort (GPC) Consortium; Fanous, Ayman H; Pato, Michele T; McCarroll, Steven A; Pato, Carlos N
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Abstract:
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of millions of individuals worldwide. While rare genetic variants play a role in the etiology of schizophrenia, most of the currently explained liability is within common variation, suggesting that variation predating the human diaspora out of Africa harbors a large fraction of the common variant attributable heritability. However, common variant association studies in schizophrenia have concentrated mainly on cohorts of European descent. We describe genome-wide association studies of 6152 cases and 3918 controls of admixed African ancestry, and of 1234 cases and 3090 controls of Latino ancestry, representing the largest such study in these populations to date. Combining results from the samples with African ancestry with summary statistics from the Psychiatric Genomics Consortium (PGC) study of schizophrenia yielded seven newly genome-wide significant loci, and we identified an additional eight loci by incorporating the results from samples with Latino ancestry. Leveraging population differences in patterns of linkage disequilibrium, we achieve improved fine-mapping resolution at 22 previously reported and 4 newly significant loci. Polygenic risk score profiling revealed improved prediction based on trans-ancestry meta-analysis results for admixed African (Nagelkerke's R2 = 0.032; liability R2 = 0.017; P < 10-52), Latino (Nagelkerke's R2 = 0.089; liability R2 = 0.021; P < 10-58), and European individuals (Nagelkerke's R2 = 0.089; liability R2 = 0.037; P < 10-113), further highlighting the advantages of incorporating data from diverse human populations.
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Keyword:
2.1 Biological and endogenous factors; Biological Sciences; Blacks; Brain Disorders; Consortium on the Genetics of Schizophrenia (COGS) Investigators; Female; Genetic Loci; Genetic Predisposition to Disease; Genetics; Genome-Wide Association Study; Genomic Psychiatry Cohort (GPC) Consortium; Hispanic or Latino; Human Genome; Humans; Male; Medical and Health Sciences; Mental Health; Polymorphism; Psychiatry; Psychology and Cognitive Sciences; Schizophrenia; Serious Mental Illness; Single Nucleotide
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URL: https://escholarship.org/uc/item/5gk7n9bq
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Health comorbidities and cognitive abilities across the lifespan in Down syndrome. ...
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Клинико-лингвистические характеристики психических нарушений при ВИЧ-инфицировании ... : Clinical and linguistic characteristics of mental disorders in HIV infection ...
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Assessing Health Related Quality of Life, Language Impairment, and Psychosocial Factors in Post-Stroke Aphasia
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In: Honors College (2020)
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Специфика обследования и коррекции речевых нарушений у пациентки с подкорковой афазией ... : Examination and rehabilitation of speech disorders in a patient with subcortical aphasia ...
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