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Evaluation of the effect of transcranial direct current stimulation on language impairments in the behavioural variant of frontotemporal dementia
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In: Brain Commun (2022)
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Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants
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In: Front Neurol (2021)
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The White Matter Module-Hub Network of Semantics Revealed by Semantic Dementia
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In: ISSN: 0898-929X ; EISSN: 1530-8898 ; Journal of Cognitive Neuroscience ; https://hal.inria.fr/hal-02554966 ; Journal of Cognitive Neuroscience, Massachusetts Institute of Technology Press (MIT Press), 2020, pp.1-18. ⟨10.1162/jocn_a_01549⟩ (2020)
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Language boosting by transcranial stimulation in progressive supranuclear palsy ; Stimulation du langage par stimulation transcrânienne dans la paralysie supranucléaire progressive
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-02415190 ; Neurology, American Academy of Neurology, 2019, 93 (6), pp.e537-e547. ⟨10.1212/WNL.0000000000007893⟩ (2019)
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Does surface dyslexia/dysgraphia relate to semantic deficits in the semantic variant of primary progressive aphasia?
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In: ISSN: 0028-3932 ; EISSN: 1873-3514 ; Neuropsychologia ; https://hal.archives-ouvertes.fr/hal-03488501 ; Neuropsychologia, Elsevier, 2019, 135, pp.107241 -. ⟨10.1016/j.neuropsychologia.2019.107241⟩ (2019)
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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In: ISSN: 1745-6215 ; Trials ; https://hal.sorbonne-universite.fr/hal-02407657 ; Trials, BioMed Central, 2019, 20 (1), pp.632. ⟨10.1186/s13063-019-3613-z⟩ (2019)
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial ...
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial ...
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| 10 |
Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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| 11 |
Language boosting by transcranial stimulation in progressive supranuclear palsy
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In: Neurology (2019)
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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| 13 |
Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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Routier, Alexandre; Habert, Marie-Odile; Bertrand, Anne; Kas, Aurélie; Sundqvist, Martina; Mertz, Justine; David, Pierre-Maxime; Bertin, Hugo; Belliard, Serge; Pasquier, Florence; Bennys, Karim; Martinaud, Olivier; Etcharry-Bouyx, Frédérique; Moreaud, Olivier; Godefroy, Olivier; Pariente, Jérémie; Puel, Michèle; Couratier, Philippe; Boutoleau-Bretonnière, Claire; Laurent, Bernard; Migliaccio, Raphaëlla; Dubois, Bruno; Colliot, Olivier; Teichmann, Marc
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In: ISSN: 1664-2295 ; Frontiers in Neurology ; https://hal.inria.fr/hal-01897015 ; Frontiers in Neurology, Frontiers, 2018, 9, ⟨10.3389/fneur.2018.00766⟩ (2018)
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Abstract:
International audience ; Neuroimaging studies have described the brain alterations in primary progressive aphasia (PPA) variants (semantic, logopenic, nonfluent/agrammatic). However, few studies combined T1, FDG-PET, and diffusion MRI techniques to study atrophy, hypometabolism, and tract alterations across the three PPA main variants. We therefore explored a large early-stage cohort of semantic, logopenic and nonfluent/agrammatic variants (N = 86) and of 23 matched healthy controls with anatomical MRI (cortical thickness), FDG PET (metabolism) and diffusion MRI (white matter tracts analyses), aiming at identifying cortical and sub-cortical brain alterations, and confronting these alterations across imaging modalities and aphasia variants. In the semantic variant, there was cortical thinning and hypometabolism in anterior temporal cortices, with left-hemisphere predominance, extending toward posterior temporal regions, and affecting tracts projecting to the anterior temporal lobes (inferior longitudinal fasciculus, uncinate fasciculus) and tracts projecting to or running nearby posterior temporal cortices: (superior longitudinal fasciculus, inferior frontal-occipital fasciculus). In the logopenic variant metabolic alterations were more extensive than atrophy affecting mainly the left temporal-parietal junction and extending toward more anterior temporal cortices. Metabolic and tract data were coherent given the alterations of the left superior and inferior longitudinal fasciculus and the left inferior frontal-occipital fasciculus. In the nonfluent/agrammatic variant cortical thinning and hypometabolism were located in the left frontal cortex but Broca's area was only affected on metabolic measures. Metabolic and tract alterations were coherent as reflected by damage to the left uncinate fasciculus connecting with Broca's area. Our findings provide a full-blown statistically robust picture of brain alterations in early-stage variants of primary progressive aphasia which has implications for diagnosis, classification and future therapeutic strategies. They demonstrate that in logopenic and semantic variants patterns of brain damage display a non-negligible overlap in temporal regions whereas they are substantially distinct in the nonfluent/agrammatic variant (frontal regions). These results also indicate that frontal networks (combinatorial syntax/phonology) and temporal networks (lexical/semantic representations) constitute distinct anatomo-functional entities with differential vulnerability to degenerative processes in aphasia variants. Finally, the identification of the specific damage patterns could open an avenue for trans-cranial stimulation approaches by indicating the appropriate target-entry into the damaged language system.
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Keyword:
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
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URL: https://hal.inria.fr/hal-01897015/file/2018_Routier_fneur-09-00766.pdf
https://doi.org/10.3389/fneur.2018.00766
https://hal.inria.fr/hal-01897015/document
https://hal.inria.fr/hal-01897015
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| 14 |
The structure of the mental lexicon: what primary progressive aphasias reveal
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In: ISSN: 0028-3932 ; EISSN: 1873-3514 ; Neuropsychologia ; https://hal.inria.fr/hal-01672932 ; Neuropsychologia, Elsevier, 2018, 109, pp.107-115. ⟨10.1016/j.neuropsychologia.2017.12.018⟩ (2018)
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| 15 |
Structural, microstructural and metabolic alterations in Primary Progressive Aphasia variants
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In: Annual meeting of the Organization for Human Brain Mapping - OHBM 2018 ; https://hal.inria.fr/hal-01764289 ; Annual meeting of the Organization for Human Brain Mapping - OHBM 2018, Jun 2018, Singapore, Singapore (2018)
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Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630161 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018)
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| 17 |
Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://www.hal.inserm.fr/inserm-02749861 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018)
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| 18 |
Parietal involvement in the semantic variant of primary progressive aphasia with Alzheimer's disease CSF profile
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In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal.sorbonne-universite.fr/hal-01928504 ; Journal of Alzheimer's Disease, IOS Press, 2018, 66 (1), pp.271 - 280. ⟨10.3233/JAD-180087⟩ (2018)
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| 19 |
An Automated Pipeline for the Analysis of PET Data on the Cortical Surface
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In: ISSN: 1662-5196 ; Frontiers in Neuroinformatics ; https://hal.inria.fr/hal-01950933 ; Frontiers in Neuroinformatics, Frontiers, 2018, 12, ⟨10.3389/fninf.2018.00094⟩ (2018)
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An Automated Pipeline for the Analysis of PET Data on the Cortical Surface
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