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Information about word class is both semantically and lexically represented: evidence from an advantage for verbs in two speakers with aphasia
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In: Aphasiology. - (2021) , ISSN: 1464-5041 (2021)
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Learning of novel compound nouns: a variant of lexical learning that requires intact verbal short-term memory
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In: Cortex. - 124 (2020) , 23-32, ISSN: 1973-8102 (2020)
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Dissociating frontal and temporal correlates of phonological and semantic fluency in a large sample of left hemisphere stroke patients. ...
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Dissociating frontal and temporal correlates of phonological and semantic fluency in a large sample of left hemisphere stroke patients
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Schmidt, Charlotte S.M.; Nitschke, Kai; Bormann, Tobias; Römer, Pia; Kümmerer, Dorothee; Martin, Markus; Umarova, Roza M.; Leonhart, Rainer; Egger, Karl; Dressing, Andrea; Musso, Mariachristina; Willmes, Klaus; Weiller, Cornelius; Kaller, Christoph P.. - : Elsevier, 2019
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Abstract:
Previous lesion studies suggest that semantic and phonological fluency are differentially subserved by distinct brain regions in the left temporal and the left frontal cortex, respectively. However, as of yet, this often implied double dissociation has not been explicitly investigated due to mainly two reasons: (i) the lack of sufficiently large samples of brain-lesioned patients that underwent assessment of the two fluency variants and (ii) the lack of tools to assess interactions in factorial analyses of non-normally distributed behavioral data. In addition, previous studies did not control for task resource artifacts potentially introduced by the generally higher task difficulty of phonological compared to semantic fluency. We addressed these issues by task-difficulty adjusted assessment of semantic and phonological fluency in 85 chronic patients with ischemic stroke of the left middle cerebral artery. For classical region-based lesion-behavior mapping patients were grouped with respect to their primary lesion location. Building on the extension of the non-parametric Brunner-Munzel rank-order test to multi-factorial designs, ANOVA-type analyses revealed a significant two-way interaction for cue type (semantic vs. phonological) by lesion location (left temporal vs. left frontal vs. other as stroke control group). Subsequent contrast analyses further confirmed the proposed double dissociation by demonstrating that (i) compared to stroke controls, left temporal lesions led to significant impairments in semantic but not in phonological fluency, whereas left frontal lesions led to significant impairments in phonological but not in semantic fluency, and that (ii) patients with frontal lesions showed significantly poorer performance in phonological than in semantic fluency, whereas patients with temporal lesions showed significantly poorer performance in semantic than in phonological fluency. The anatomical specificity of these findings was further assessed in voxel-based lesion-behavior mapping analyses using the multi-factorial extension of the Brunner-Munzel test. Voxel-wise ANOVA-type analyses identified circumscribed parts of left inferior frontal gyrus and left superior and middle temporal gyrus that significantly double-dissociated with respect to their differential contribution to phonological and semantic fluency, respectively. Furthermore, a main effect of lesion with significant impairments in both fluency types was found in left inferior frontal regions adjacent to but not overlapping with those showing the differential effect for phonological fluency. The present study hence not only provides first explicit evidence for the anatomical double dissociation in verbal fluency at the group level but also clearly underlines that its formulation constitutes an oversimplification as parts of left frontal cortex appear to contribute to both semantic and phonological fluency.
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Keyword:
Regular Article
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URL: http://www.ncbi.nlm.nih.gov/pubmed/31108458
https://doi.org/10.1016/j.nicl.2019.101840
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526291/
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Dissociating frontal and temporal correlates of phonological and semantic fluency in a large sample of left hemisphere stroke patients
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In: NeuroImage: clinical. - 23 (2019) , 101840, ISSN: 2213-1582 (2019)
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Asymmetries of amyloid-{beta} burden and neuronal dysfunction are positively correlated in Alzheimer's disease
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Cortical and fibre tract interrelations in conduction aphasia
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In: Aphasiology. - 28, 10 (2014) , 1151-1167, ISSN: 0268-7038 (2014)
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Morphological-compound dysgraphia in an aphasic patient: “A wild write through the lexicon”
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In: Cognitive Neuropsychology. - 31, 1-2 (2014) , 75-105, ISSN: 0264-3294 (2014)
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Semantic and phonological information in sentence recall: Converging psycholinguistic and neuropsychological evidence
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In: Cognitive Neuropsychology. - 28, 8 (2011) , 521-545, ISSN: 0264-3294 (2012)
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The Role of Lexical-Semantic Neighborhood in Object Naming: Implications for Models of Lexical Access
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The role of lexical-semantic neighborhood in object naming: implications for models of lexical access
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In: Frontiers in psychology. - 2 (2011) , 00127, ISSN: 1664-1078 (2011)
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Verbal planning in a case of ‘Dynamic Aphasia’: An impairment at the level of macroplanning
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In: Neurocase. - 14, 5 (2008) , 431-450, ISSN: 1355-4794 (2008)
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Writing two words as one: Word boundary errors in a German case of acquired surface dysgraphia
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In: Journal of Neurolinguistics. - 22, 1 (2009) , 74-82, ISSN: 0911-6044 (2008)
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“Fragment errors” in deep dysgraphia: Further support for a lexical hypothesis
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In: Cognitive Neuropsychology. - 25, 5 (2008) , 745-764, ISSN: 0264-3294 (2008)
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Fallstudien zur mündlichen und schriftlichen Sprachproduktion aphasischer und dementer Patienten ... : Case studies of oral and written language production in patients with aphasia and dementia ...
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The Dissolution of spoken word production in aphasia : implications for normal functions
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The dissolution of spoken word production in aphasia: Implications for normal functions
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In: Multidisciplinary Approaches to Language Production. Berlin / New York. Thomas Pechmann / Christopher Habel - 303 - 338. (2004)
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