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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 5 of 5 1 Genome-wide screening for DNA variants associated with reading and language traits Gialluisi, Alessandro; Newbury, Dianne F; Wilcutt, Erik G; Olson, Richard K; DeFries, John C; Brandler, William M; Pennington, Bruce F; Smith, Shelley D; Scerri, Thomas S; Simpson, Nuala H; The SLI Consortium; Luciano, Michelle; Evans, David M; Bates, Timothy C; Stein, John F; Talcott, Joel B; Monaco, Anthony P; Paracchini, Silvia; Francks, Clyde; Fisher, Simon E. - 2015 Abstract: This research was funded by: Max Planck Society, the University of St Andrews - Grant Number: 018696, US National Institutes of Health - Grant Number: P50 HD027802, Wellcome Trust - Grant Number: 090532/Z/09/Z, and Medical Research Council Hub Grant Grant Number: G0900747 91070 ; Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome‐wide association scan (GWAS) meta‐analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading‐ and language‐related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10–7 for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on‐going international efforts to identify genes contributing to reading and language skills. ; Publisher PDF ; Peer reviewed Keyword: BDC; BF; BF Psychology; CLDRC; Developmental dyslexia; GWAS; Language; Meta-analysis; Pleiotropic variants; QH426; QH426 Genetics; Reading; Reading disability; SLIC; Specific language impairment URL: http://hdl.handle.net/10023/6497 https://onlinelibrary.wiley.com/doi/full/10.1111/gbb.12158#support-information-section https://doi.org/10.1111/gbb.12158 BASE Hide details 2 Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample Lind, Penelope A; Luciano, Michelle; Wright, Margaret J. - : Nature Publishing Group, 2010 BASE Show details 3 Genetic and environmental bases of reading and spelling : a unified genetic dual route model Bates, Timothy C; Castles, Anne; Luciano, Michelle. - : Springer Netherlands, 2007 BASE Show details 4 John Marshall and the developmental dyslexias Castles, Anne; Bates, Timothy C; Coltheart, Max. - : Psychology Press, 2006 BASE Show details 5 Crystallized intelligence as a product of speed and drive for experience : the relationship of inspection time and openness to g and Gc Bates, Timothy C; Shieles, Alexandra. - : Elsevier, 2003 BASE Show details

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