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Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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Sanches, Clara; Levy, Richard; Benisty, Sarah; Volpe-Gillot, Lisette; Habert, Marie-Odile; Kas, Aurélie; Ströer, Sébastian; Pyatigorskaya, Nadya; Kaglik, Anna; Bourbon, Angelina; Dubois, Bruno; Migliaccio, Raffaella; Valero-Cabré, Antoni; Teichmann, Marc
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In: ISSN: 1745-6215 ; Trials ; https://hal.sorbonne-universite.fr/hal-02407657 ; Trials, BioMed Central, 2019, 20 (1), pp.632. ⟨10.1186/s13063-019-3613-z⟩ (2019)
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Abstract:
International audience ; BACKGROUND: Semantic dementia is a neurodegenerative disease that primarily affects the left anterior temporal lobe, resulting in a gradual loss of conceptual knowledge. There is currently no validated treatment. Transcranial stimulation has provided evidence for long-lasting language effects presumably linked to stimulation-induced neuroplasticity in post-stroke aphasia. However, studies evaluating its effects in neurodegenerative diseases such as semantic dementia are still rare and evidence from double-blind, prospective, therapeutic trials is required.OBJECTIVE: The primary objective of the present clinical trial (STIM-SD) is to evaluate the therapeutic efficacy of a multiday transcranial direct current stimulation (tDCS) regime on language impairment in patients with semantic dementia. The study also explores the time course of potential tDCS-driven improvements and uses imaging biomarkers that could reflect stimulation-induced neuroplasticity.METHODS: This is a double-blind, sham-controlled, randomized study using transcranial Direct Current Stimulation (tDCS) applied daily for 10 days, and language/semantic and imaging assessments at four time points: baseline, 3 days, 2 weeks and 4 months after 10 stimulation sessions. Language/semantic assessments will be carried out at these same 4 time points. Fluorodeoxyglucose positron emission tomography (FDG-PET), resting-state functional magnetic resonance imaging (rs-fMRI), T1-weighted images and white matter diffusion tensor imaging (DTI) will be applied at baseline and at the 2-week time point. According to the principle of inter-hemispheric inhibition between left (language-related) and right homotopic regions we will use two stimulation modalities - left-anodal and right-cathodal tDCS over the anterior temporal lobes. Accordingly, the patient population (n = 60) will be subdivided into three subgroups: left-anodal tDCS (n = 20), right-cathodal tDCS (n = 20) and sham tDCS (n = 20). The stimulation will be sustained for 20 min at an intensity of 1.59 mA. It will be delivered through 25cm2-round stimulation electrodes (current density of 0.06 mA/cm2) placed over the left and right anterior temporal lobes for anodal and cathodal stimulation, respectively. A group of healthy participants (n = 20) matched by age, gender and education will also be recruited and tested to provide normative values for the language/semantic tasks and imaging measures.DISCUSSION: The aim of this study is to assess the efficacy of tDCS for language/semantic disorders in semantic dementia. A potential treatment would be easily applicable, inexpensive, and renewable when therapeutic effects disappear due to disease progression.
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Keyword:
[SDV.IB]Life Sciences [q-bio]/Bioengineering; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; Language impairments; Neurodegenerative diseases; Neurology; Non-invasive brain stimulation; Primary progressive aphasia; Semantic dementia; Transcranial direct current stimulation
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URL: https://doi.org/10.1186/s13063-019-3613-z
https://hal.sorbonne-universite.fr/hal-02407657
https://hal.sorbonne-universite.fr/hal-02407657/file/document%281%29.pdf
https://hal.sorbonne-universite.fr/hal-02407657/document
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| 3 |
Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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In: ISSN: 1664-2295 ; Frontiers in Neurology ; https://hal.inria.fr/hal-01897015 ; Frontiers in Neurology, Frontiers, 2018, 9, ⟨10.3389/fneur.2018.00766⟩ (2018)
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| 4 |
The structure of the mental lexicon: what primary progressive aphasias reveal
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In: ISSN: 0028-3932 ; EISSN: 1873-3514 ; Neuropsychologia ; https://hal.inria.fr/hal-01672932 ; Neuropsychologia, Elsevier, 2018, 109, pp.107-115. ⟨10.1016/j.neuropsychologia.2017.12.018⟩ (2018)
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Structural, microstructural and metabolic alterations in Primary Progressive Aphasia variants
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In: Annual meeting of the Organization for Human Brain Mapping - OHBM 2018 ; https://hal.inria.fr/hal-01764289 ; Annual meeting of the Organization for Human Brain Mapping - OHBM 2018, Jun 2018, Singapore, Singapore (2018)
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| 6 |
Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://www.hal.inserm.fr/inserm-02749861 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018)
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Parietal involvement in the semantic variant of primary progressive aphasia with Alzheimer's disease CSF profile
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In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal.sorbonne-universite.fr/hal-01928504 ; Journal of Alzheimer's Disease, IOS Press, 2018, 66 (1), pp.271 - 280. ⟨10.3233/JAD-180087⟩ (2018)
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An Automated Pipeline for the Analysis of PET Data on the Cortical Surface
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In: ISSN: 1662-5196 ; Frontiers in Neuroinformatics ; https://hal.inria.fr/hal-01950933 ; Frontiers in Neuroinformatics, Frontiers, 2018, 12, ⟨10.3389/fninf.2018.00094⟩ (2018)
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Free and Cued Selective Reminding Test – accuracy for the differential diagnosis of Alzheimer's and neurodegenerative diseases: A large-scale biomarker-characterized monocenter cohort study (ClinAD)
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In: ISSN: 1552-5260 ; Alzheimer's and Dementia ; https://hal.inria.fr/hal-01672862 ; Alzheimer's and Dementia, Elsevier, 2017, 13 (8), pp.913 - 923. ⟨10.1016/j.jalz.2016.12.014⟩ (2017)
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| 10 |
Direct current stimulation over the anterior temporal areas boosts semantic processing in primary progressive aphasia
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://hal.inria.fr/hal-01377876 ; Annals of Neurology, Wiley, 2016 (2016)
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| 11 |
The Brain Network of Naming: A Lesson from Primary Progressive Aphasia
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In: ISSN: 1932-6203 ; EISSN: 1932-6203 ; PLoS ONE ; https://hal.sorbonne-universite.fr/hal-01294408 ; PLoS ONE, Public Library of Science, 2016, 11 (2), pp.e0148707. ⟨10.1371/journal.pone.0148707⟩ (2016)
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| 12 |
Deciphering logopenic primary progressive aphasia: a clinical, imaging and biomarker investigation.
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In: ISSN: 0006-8950 ; EISSN: 1460-2156 ; Brain - A Journal of Neurology ; https://hal.inria.fr/hal-00938644 ; Brain - A Journal of Neurology , Oxford University Press (OUP), 2013, 136 (11), pp.3474-3488. ⟨10.1093/brain/awt266⟩ (2013)
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