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1
Tractography of supplementary motor area projections in progressive speech apraxia and aphasia
In: Neuroimage Clin (2022)
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2
A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech
In: Nat Commun (2021)
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3
Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia
In: Brain Lang (2019)
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4
The influence of β-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia
Whitwell, Jennifer L.; Martin, Peter R.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2019
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5
[18F]AV-1451 tau-PET and primary progressive aphasia
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6
Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech
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7
Disrupted functional connectivity in primary progressive apraxia of speech
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8
Tau-PET imaging with [18F]AV-1451 in Primary Progressive Apraxia of Speech
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9
Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech
Abstract: Primary progressive apraxia of speech (PPAOS) is a clinical syndrome in which apraxia of speech is the initial indication of neurodegenerative disease. Prior studies of PPAOS have identified hypometabolism, grey matter atrophy, and white matter tract degeneration in the frontal gyri, precentral cortex, and supplementary motor area (SMA). Recent clinical observations suggest two distinct subtypes of PPAOS may exist. Phonetic PPAOS is characterized predominantly by distorted sound substitutions. Prosodic PPAOS is characterized predominantly by slow, segmented speech. Demographic, clinical, and neuroimaging data (MRI, DTI, and FDG-PET) were analyzed to validate these subtypes and explore anatomic correlates. The Phonetic subtype demonstrated bilateral involvement of the SMA, precentral gyrus, and cerebellar crus. The Prosodic subtype demonstrated more focal involvement in the SMA and right superior cerebellar peduncle. The findings provide converging evidence that differences in the reliably determined predominant clinical characteristics of AOS are associated with distinct imaging patterns, independent of severity.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pubmed/29980072
https://doi.org/10.1016/j.bandl.2018.06.004
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171111/
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10
Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech
Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2017
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11
Tracking the Development of Agrammatic Aphasia: a Tensor-Based Morphometry Study
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