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1	Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
	Ljubenkov, Peter A; Staffaroni, Adam M; Rojas, Julio C; Allen, Isabel E; Wang, Ping; Heuer, Hilary; Karydas, Anna; Kornak, John; Cobigo, Yann; Seeley, William W; Grinberg, Lea T; Spina, Salvatore; Fagan, Anne M; Jerome, Gina; Knopman, David; Boeve, Brad F; Dickerson, Bradford C; Kramer, Joel; Miller, Bruce; Boxer, Adam L; Rosen, Howard J
	In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
	Abstract: ObjectiveThe prognostic value of cerebrospinal fluid neurofilament light chain, total tau, phosphorylated tau181, and amyloid beta1-42 was examined in frontotemporal dementia subtypes.MethodsWe compared baseline biomarkers between 49 controls, 40 patients with behavioral variant frontotemporal dementia, 24 with semantic variant primary progressive aphasia, and 26 with nonfluent variant primary progressive aphasia. Linear mixed effect models were used to assess the value of baseline biomarkers in predicting clinical and radiographic change in patient cohorts over multiple yearly follow up visits.ResultsNeurofilament light chain concentrations were lowest in controls. Elevated baseline neurofilament light chain predicted faster worsening in clinical severity, frontotemporal volume and frontotemporal fractional anisotropy in patients with behavioral variant frontotemporal dementia and nonfluent variant primary progressive aphasia. High total tau similarly predicted faster progression in nonfluent variant primary progressive aphasia. In behavioral variant frontotemporal dementia, higher phosphorylated tau181 predicted faster clinical progression whereas lower amyloid beta1-42 predicted faster volumetric and fractional anisotropy reduction. Neurofilament light chain and phosphorylated tau181 were of greater predictive value in patients with tau pathology as compared to TDP-43 pathology. Baseline neurofilament light chain correlated with baseline clinical severity and frontotemporal volume in behavioral variant frontotemporal dementia. Baseline total tau correlated with baseline clinical severity in semantic variant primary progressive aphasia.InterpretationHigh cerebrospinal fluid neurofilament light chain predicts more aggressive disease in behavioral variant frontotemporal dementia and nonfluent variant primary progressive aphasia. Total tau, phosphorylated tau181, and amyloid beta1-42 also predict some measures of disease aggressiveness in frontotemporal dementia.
	Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Aphasia; Brain Disorders; Clinical Research; Clinical Sciences; Dementia; Frontotemporal Dementia (FTD); Neurodegenerative; Neurological; Neurosciences
	URL: https://escholarship.org/uc/item/74t3v9p8
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